Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9799821 | 0.85 | TDP1 (0.62) | TDP1ALDH1A1TSHRMAPK1MAPT | |
| SCHEMBL13721530 | 0.85 | TDP1 (0.57) | TDP1ALDH1A1TSHRMAPK1MAPT | |
| SCHEMBL19783654 | 0.81 | TDP1 (0.52) | TDP1ALDH1A1TSHRMAPK1MAPT | |
| SCHEMBL936742 | 0.80 | TDP1 (0.60) | TDP1ALDH1A1TSHRMAPK1MAPT | |
| SCHEMBL6973058 | 0.80 | ALDH1A1 (0.52) | TDP1ALDH1A1TSHRMAPK1MAPT | |
| SCHEMBL4864448 | 0.79 | TDP1 (0.57) | TDP1ALDH1A1TSHRMAPK1MAPT | |
| SCHEMBL7351196 | 0.79 | TSHR (0.49) | TDP1ALDH1A1TSHRMAPTLMNA | |
| SCHEMBL21295439 | 0.79 | TSHR (0.44) | TDP1ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL31118308 | 0.79 | TPMT (0.47) | TDP1ALDH1A1TSHRMAPK1MAPT | |
| SCHEMBL17744425 | 0.79 | ALDH1A1 (0.47) | TDP1ALDH1A1TSHRMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867432-B1 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | AVENTIS PHARMA GMBH (DE) | 2004-06-09 | — | — | EP | disclosed |
| US-6211196-B1 | 8-BENZYLOXY-(TETRAHYDRO)QUINOLINE DERIVATIVES; LIVER CIRRHOSIS, ALZHEIMER*S DISEASE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-04-03 | — | — | US | disclosed |
| US-6071917-A | ANALGESICS; ANTIINFLAMMATORY AGENTS; ESPECIALLY FOR THE TREATMENT OF ASTHMA, CEREBRAL TRAUMATIC SHOCK AND ALLERGIC RHINITIS; COMPETITIVE BINDING AT RECEPTORS | FOURNIER INDUSTRIE ET SANTE (FR) | 2000-06-06 | — | — | US | disclosed |
| EP-0925295-A1 | N-BENZENESULPHONYL-L-PROLINE DERIVATIVES AS BRADYKININ B2 AGONISTS | FOURNIER INDUSTRIE ET SANTE (FR) | 1999-06-30 | — | — | EP | disclosed |
| US-5834500-A | ADMINISTERING DERIVATIVES OF BENZYLOXY-BENZOTHIAZENES TO CONTROL RELEASE OF PROSTAGLANDINS, LEUKOTRIENES, HISTAMINES, TACHYKININS, THROMBOXANES; ANALGESICS, ANTIASTHMATIC, ANTIINFLAMMATORY, WOUND HEALING AND ANTITUMOR AGENTSAGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-11-10 | — | — | US | disclosed |
| EP-0867432-A2 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-30 | — | — | EP | disclosed |
| WO-1998003503-A1 | N-BENZENESULPHONYL-L-PROLINE DERIVATIVES AS BRADYKININ B2 AGONISTS | FOURNIER INDUSTRIE ET SANTE (FR) | 1998-01-29 | — | — | WO | disclosed |