Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.42 |
| ▸ | MEP1B | Q16820 | 5/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6577652 | 0.88 | CYP4F2 (0.52) | FOLH1MRGPRX4HIF1AIDO1 | |
| SCHEMBL6577714 | 0.83 | GRM2 (0.41) | GRM2GRM3FOLH1MEP1BMRGPRX4 | |
| SCHEMBL27760814 | 0.75 | FOLH1 (0.58) | GRM2GRM3FOLH1MEP1BMRGPRX4 | |
| SCHEMBL6577612 | 0.72 | CYP4F2 (0.53) | FOLH1MRGPRX4HIF1AIDO1 | |
| SCHEMBL17459846 | 0.72 | FOLH1 (0.54) | GRM2GRM3FOLH1MRGPRX4CYP2D6 | |
| SCHEMBL30395109 | 0.71 | FOLH1 (0.66) | FOLH1MRGPRX4KMT2ACYP2D6CYP2C9 | |
| SCHEMBL1817886 | 0.71 | FOLH1 (0.66) | FOLH1MRGPRX4KMT2ACYP2D6CYP2C9 | |
| SCHEMBL28374573 | 0.71 | NR1H4 (0.59) | FOLH1MRGPRX4NR1H4 | |
| SCHEMBL371526 | 0.71 | FOLH1 (0.70) | FOLH1MEP1BMRGPRX4KMT2ACYP2D6 | |
| SCHEMBL848969 | 0.70 | FOLH1 (0.56) | FOLH1MEP1BMRGPRX4ANPEPENPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383730-A2 | ANTICHOLINERGIC COMPOUNDS AND METHODS OF USE | Aryx Therapeutics (US) | 2004-01-28 | — | — | EP | claimed |
| WO-2002096855-A2 | ANTICHOLINERGIC COMPOUNDS AND METHODS OF USE | ARYX THERAPEUTICS (US) | 2002-12-05 | — | — | WO | claimed |