Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6581247 | 0.86 | ALDH1A1 (0.46) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL4351741 | 0.77 | ALDH1A1 (0.46) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL6520014 | 0.77 | ALDH1A1 (0.46) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL6519971 | 0.76 | ALDH1A1 (0.45) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL6576208 | 0.76 | TDP1 (0.45) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL28092308 | 0.74 | MAPT (0.48) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL7880793 | 0.73 | RECQL (0.45) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL6580757 | 0.73 | MEN1 (0.54) | ALDH1A1LMNANPC1RAB9AKMT2A | |
| SCHEMBL34472127 | 0.73 | ALDH1A1 (0.45) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL11404648 | 0.73 | TDP1 (0.45) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867432-B1 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | AVENTIS PHARMA GMBH (DE) | 2004-06-09 | — | — | EP | disclosed |
| US-6211196-B1 | 8-BENZYLOXY-(TETRAHYDRO)QUINOLINE DERIVATIVES; LIVER CIRRHOSIS, ALZHEIMER*S DISEASE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-04-03 | — | — | US | disclosed |
| EP-0867432-A2 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-30 | — | — | EP | disclosed |