Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11404648 | 0.88 | TDP1 (0.45) | TDP1ALDH1A1L3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL6520014 | 0.83 | ALDH1A1 (0.46) | TDP1ALDH1A1L3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL6581247 | 0.83 | ALDH1A1 (0.46) | TDP1ALDH1A1L3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL6519971 | 0.81 | ALDH1A1 (0.45) | TDP1ALDH1A1L3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL4980012 | 0.80 | TDP1 (0.57) | TDP1ALDH1A1L3MBTL1LMNAMEN1 | |
| SCHEMBL31503717 | 0.80 | TDP1 (0.57) | TDP1ALDH1A1L3MBTL1LMNAMEN1 | |
| SCHEMBL4351741 | 0.79 | ALDH1A1 (0.46) | TDP1ALDH1A1L3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL35211710 | 0.79 | TDP1 (0.49) | TDP1ALDH1A1L3MBTL1LMNAMEN1 | |
| SCHEMBL6576203 | 0.78 | TDP1 (0.60) | TDP1ALDH1A1LMNAMAPK1 | |
| SCHEMBL34472127 | 0.78 | ALDH1A1 (0.45) | TDP1ALDH1A1L3MBTL1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867432-B1 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | AVENTIS PHARMA GMBH (DE) | 2004-06-09 | — | — | EP | disclosed |
| US-6211196-B1 | 8-BENZYLOXY-(TETRAHYDRO)QUINOLINE DERIVATIVES; LIVER CIRRHOSIS, ALZHEIMER*S DISEASE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-04-03 | — | — | US | disclosed |
| EP-0867432-A2 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-30 | — | — | EP | disclosed |