Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL278628 | 0.85 | TDP1 (0.60) | TDP1TSHRMAPK1VCAM1ALDH1A1 | |
| SCHEMBL6640405 | 0.83 | TDP1 (0.62) | TDP1TSHRMAPK1VCAM1ALDH1A1 | |
| SCHEMBL6646572 | 0.81 | TDP1 (0.60) | TDP1TSHRMAPK1VCAM1ALDH1A1 | |
| SCHEMBL4922982 | 0.81 | TDP1 (0.60) | TDP1TSHRMAPK1VCAM1ALDH1A1 | |
| SCHEMBL2130580 | 0.79 | TDP1 (0.47) | TDP1TSHRMAPK1VCAM1ALDH1A1 | |
| SCHEMBL31514206 | 0.79 | TDP1 (0.56) | TDP1TSHRMAPK1VCAM1ALDH1A1 | |
| SCHEMBL5042301 | 0.79 | TDP1 (0.56) | TDP1TSHRMAPK1VCAM1ALDH1A1 | |
| SCHEMBL6581245 | 0.78 | VCAM1 (0.47) | TDP1TSHRMAPK1VCAM1ALDH1A1 | |
| SCHEMBL6578580 | 0.78 | TDP1 (0.47) | TDP1TSHRMAPK1VCAM1ALDH1A1 | |
| SCHEMBL6576208 | 0.78 | TDP1 (0.45) | TDP1MAPK1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1914236-A1 | Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators | Ortho-McNeil Pharmaceutical, Inc. (US) | 2008-04-23 | — | — | EP | disclosed |
| US-7358261-B2 | Heteroaryl alkylamide derivatives useful as bradykinin receptor modulators | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-04-15 | — | — | US | disclosed |
| EP-0867432-B1 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | AVENTIS PHARMA GMBH (DE) | 2004-06-09 | — | — | EP | disclosed |
| EP-0808838-B1 | Sulfur-containing heterocyclic bradykinin antagonists, processes for their production and use thereof | HOECHST AG (DE) | 2003-10-22 | — | — | EP | disclosed |
| EP-0796848-B1 | Fluoralkyl- and fluoralkoxy-substituted heterocyclic bradykinin antagonists | HOECHST AG (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6211196-B1 | 8-BENZYLOXY-(TETRAHYDRO)QUINOLINE DERIVATIVES; LIVER CIRRHOSIS, ALZHEIMER*S DISEASE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-04-03 | — | — | US | disclosed |
| WO-2000069435-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-11-23 | — | — | WO | disclosed |
| US-6110911-A | ADMINISTERING NEUROPROTECTANT/ANTICONVULSANT TO PATIENT | WARNER-LAMBERT COMPANY (US) | 2000-08-29 | — | — | US | disclosed |
| US-6015800-A | Substituted quinoxaline-2-ones as glutamate receptor antagonists | WARNER-LAMBERT COMPANY (US) | 2000-01-18 | — | — | US | disclosed |
| US-5859025-A | PAIN RELIEVERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-01-12 | — | — | US | disclosed |
| US-5750699-A | HALOGENATING OF CORRESPONDING COMPOUND | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-12 | — | — | US | disclosed |
| EP-0808838-A1 | Sulfur-containing heterocyclic bradykinin antagonists, processes for their production and use thereof | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-26 | — | — | EP | disclosed |
| CN-1163267-A | Fluoroalkyl-and-fluoroalkoxyl substituted heterocyclo bradykinin antagonist and its preparing method and use | HOECHST AG (DE) | 1997-10-29 | — | — | CN | disclosed |
| EP-0796848-A1 | Fluoralkyl- and fluoralkoxy-substituted heterocyclic bradykinin antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-09-24 | — | — | EP | disclosed |
| US-5574042-A | ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN | FUJISAWA PHARMACEUTICAL CO., LTD (JP) | 1996-11-12 | — | — | US | disclosed |
| EP-0596406-A1 | Imidazo (1,2-a) Pyridines as bradykinin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-05-11 | — | — | EP | disclosed |
| EP-0062659-A4 | 3-(PYRROL-1-YL)PHENYLMETHYL ESTERS AND INTERMEDIATES. | FMC CORP (US) | 1983-01-14 | — | — | EP | disclosed |
| EP-0062659-A1 | 3-(PYRROL-1-YL)PHENYLMETHYL ESTERS AND INTERMEDIATES | FMC Corporation (US) | 1982-10-20 | — | — | EP | disclosed |
| US-4339457-A | OF CYCLOPROPANECARBOXYLIC ACIDS, INSECTICIDES, MITICIDES | FMC CORPORATION (US) | 1982-07-13 | — | — | US | disclosed |
| WO-1982001368-A1 | 3-(PYRROL-1-YL)PHENYLMETHYL ESTERS AND INTERMEDIATES | FMC CORP (US) | 1982-04-29 | — | — | WO | disclosed |