SCHEMBL6578237

SCHEMBL6578237

CCC(F)(F)C(F)CNC(=O)Cn1ccnc1[N+](=O)[O-]

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.58
THRB P10828 1/20 0.58
CYP2C19 P33261 1/20 0.58
CYP3A4 P08684 1/20 0.54
CYP2D6 P10635 1/20 0.54
OPRK1 P41145 1/20 0.54
CA12 O43570 5/20 0.50
CA1 P00915 5/20 0.50
CA2 P00918 5/20 0.50
CA9 Q16790 5/20 0.50
KMT2A Q03164 1/20 0.41
FPR2 P25090 1/20 0.35
TYMP P19971 3/20 0.34
NOS1 P29475 1/20 0.34
ELANE P08246 1/20 0.33
MITF O75030 1/20 0.32
GRIN2B Q13224 1/20 0.31
CCR10 P46092 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL367605 0.82 LMNA (0.62) LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL6578379 0.80 LMNA (0.67) LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL15610852 0.79 LMNA (0.65) LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL367133 0.79 LMNA (0.68) LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL14499615 0.78 LMNA (0.78) LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL14023821 0.77 LMNA (0.62) LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL365988 0.77 LMNA (0.65) LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL2830638 0.77 LMNA (0.73) LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL29415206 0.77 LMNA (0.65) LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL14023806 0.77 LMNA (0.68) LMNATHRBCYP2C19CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1202973-A4 PREPARATION OF COMPOUNDS USEFUL FOR THE DETECTION OF HYPOXIA UNIV PENNSYLVANIA (US) 2004-08-18 EP disclosed
EP-1202973-A1 PREPARATION OF COMPOUNDS USEFUL FOR THE DETECTION OF HYPOXIA THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2002-05-08 EP disclosed
WO-2001007414-A1 PREPARATION OF COMPOUNDS USEFUL FOR THE DETECTION OF HYPOXIA THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2001-02-01 WO disclosed