SCHEMBL2830638

SCHEMBL2830638

O=C(Cn1ccnc1[N+](=O)[O-])NCCC(F)(F)F

nearest known ligand 0.73

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.73
THRB P10828 1/20 0.73
CYP2C19 P33261 1/20 0.73
CYP3A4 P08684 1/20 0.60
CYP2D6 P10635 1/20 0.60
OPRK1 P41145 1/20 0.60
CA12 O43570 5/20 0.58
CA1 P00915 5/20 0.58
CA2 P00918 5/20 0.58
CA9 Q16790 5/20 0.58
KMT2A Q03164 3/20 0.40
TYMP P19971 3/20 0.38
FPR2 P25090 1/20 0.36
NOS1 P29475 1/20 0.35
MEN1 O00255 2/20 0.35
ALDH1A1 P00352 2/20 0.35
MAPT P10636 1/20 0.35
TAAR1 Q96RJ0 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6578379 0.88 LMNA (0.67) LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL367133 0.87 LMNA (0.68) LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL368130 0.86 LMNA (0.78) LMNATHRBCYP2C19CYP3A4CYP2D6
Etanidazole SCHEMBL4414 0.84 LMNA (1.00) LMNATHRBCYP2C19CYP3A4CYP2D6
Etanidazole SCHEMBL8171462 0.84 LMNA (1.00) LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL13065132 0.84 LMNA (0.74) LMNATHRBCYP2C19CYP3A4CYP2D6
Etanidazole SCHEMBL9473771 0.83 LMNA (0.97) LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL8432165 0.83 LMNA (0.78) LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL14499615 0.83 LMNA (0.78) LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL15610852 0.82 LMNA (0.65) LMNATHRBCYP2C19CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118351986-A Textile product chemical footprint accounting method based on machine learning algorithm 雅戈尔服装控股有限公司 2024-07-16 CN claimed
US-7108846-B1 Methods for preparing perfluorinated [18f]-radiolabelled nitroimidazole derivatives for cellular hypoxia detection UNIVERSITE CATHOLIQUE DE LOUVAN (BE) 2006-09-19 US claimed
EP-1202945-B1 METHODS FOR PREPARING PERFLUORINATED [18 F]-RADIOLABELLED NITROIMIDAZOLE DERIVATIVES FOR CELLULAR HYPOXIA DETECTION UNIV CATHOLIQUE LOUVAIN (BE) 2005-08-17 EP claimed
EP-1202945-A1 METHODS FOR PREPARING PERFLUORINATED [18 F]-RADIOLABELLED NITROIMIDAZOLE DERIVATIVES FOR CELLULAR HYPOXIA DETECTION UNIVERSITE CATHOLIQUE DE LOUVAIN (BE) 2002-05-08 EP claimed
WO-2001012575-A1 METHODS FOR PREPARING PERFLUORINATED [18F]-RADIOLABELLED NITROIMIDAZOLE DERIVATIVES FOR CELLULAR HYPOXIA DETECTION UNIVERSITE CATHOLIQUE DE LOUVAIN (BE) 2001-02-22 WO claimed
US-20260118497-A1 Doppler Velocity Recovery and Dealiasing Algorithm for Multi-PRT Scans in Weather Radars UNIV OKLAHOMA (US) 2026-04-30 US disclosed
US-20260062716-A1 LIPID NANOPARTICLE (LNP) COMPOSITION OR FORMULATION FOR NUCLEIC ACID THERAPEUTICS POPVAX PRIVATE LTD (IN) 2026-03-05 US disclosed
US-20250388585-A1 PRMT5 INHIBITORS AND USES THEREOF GILEAD SCIENCES INC (US) 2025-12-25 US disclosed
US-12448388-B2 PRMT5 inhibitors and uses thereof GILEAD SCIENCES, INC. (US) 2025-10-21 US disclosed
WO-2025217623-A1 DOPPLER VELOCITY RECOVERY AND DEALIASING ALGORITHM FOR MULTI-PRT SCANS IN WEATHER RADARS THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) 2025-10-16 WO disclosed
US-12434104-B2 Method for managing the use of an exercise machine by multiple users for performing physical exercises and exercise machine implementing such a method TECHNOGYM S.P.A. (IT) 2025-10-07 US disclosed
US-12348431-B1 Automated scaling of packet processing service resources AMAZON TECHNOLOGIES, INC. (US) 2025-07-01 US disclosed
WO-2008054824-A9 METHODS FOR DIFFERENTIAL DETECTION OF HYPOXIC TISSUE IN A MAMMALIAN SUBJECT TRUSTESS OF THE UNIVERSITY OF (US) 2008-08-21 WO disclosed
WO-2008054824-A2 METHODS FOR DIFFERENTIAL DETECTION OF HYPOXIC TISSUE IN A MAMMALIAN SUBJECT THE TRUSTESS OF THE UNIVERSITY OF PENNSYLVANIA (US) 2008-05-08 WO disclosed
US-7230115-B1 Preparation of compounds useful for the detection of hypoxia THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2007-06-12 US disclosed
US-7108846-B1 Methods for preparing perfluorinated [18f]-radiolabelled nitroimidazole derivatives for cellular hypoxia detection UNIVERSITE CATHOLIQUE DE LOUVAN (BE) 2006-09-19 US disclosed
US-20060159618-A1 Preparation of compounds useful for the detection of hypoxia THE UNIVERSITY OF PENNSYLVANIA 2006-07-20 US disclosed
US-6855828-B1 Detection of hypoxia THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2005-02-15 US disclosed
US-20050026974-A1 Detection of hypoxia TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 2005-02-03 US disclosed
US-6252087-B1 COMPLEXING WITH A PROTEIN THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 2001-06-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250388585-A1 PRMT5 INHIBITORS AND USES THEREOF PRMT1, PRMT5, PRMT6 LMNA 1373/4885THRB 1508/4885CYP2C19 4791/4885
US-20260118497-A1 Doppler Velocity Recovery and Dealiasing Algorithm for Multi-PRT Scans in Weather Radars PRF1, VEGFA, RYR2 LMNA 1460/4885THRB 1813/4885CYP2C19 1519/4885
US-20050026974-A1 Detection of hypoxia HIF1A, HIF1AN, HYOU1 LMNA 4407/4885THRB 3873/4885CYP2C19 3405/4885
US-20060159618-A1 Preparation of compounds useful for the detection of hypoxia HIF1AN, HIF1A, HYOU1 LMNA 1709/4885THRB 2268/4885CYP2C19 2131/4885
US-12448388-B2 PRMT5 inhibitors and uses thereof PRMT5, PRMT1, PRMT9 LMNA 2517/4885THRB 3384/4885CYP2C19 4284/4885
US-20260062716-A1 LIPID NANOPARTICLE (LNP) COMPOSITION OR FORMULATION FOR NUCLEIC ACID THERAPEUTICS CETP, PLTP, LDLR LMNA 123/4885THRB 2528/4885CYP2C19 4186/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.