Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18973672 | 0.79 | MAPT (0.37) | HTR1AHTR2CHTR2B | |
| SCHEMBL25093088 | 0.79 | L3MBTL1 (0.34) | CHRM2CHRM1 | |
| SCHEMBL20705723 | 0.79 | CHRM3 (0.48) | HTR1AHTR2AHTR2CHTR2BCHRM3 | |
| SCHEMBL7421714 | 0.76 | ESR1 (0.39) | CHRM3CHRM2CHRM1 | |
| SCHEMBL17049867 | 0.76 | MAPT (0.38) | HTR1A | |
| SCHEMBL17049866 | 0.74 | SRD5A1 (0.41) | HTR1A | |
| SCHEMBL9230128 | 0.71 | POLB (0.51) | CHRM3CHRM2CHRM1 | |
| SCHEMBL15222054 | 0.71 | POLB (0.51) | CHRM3CHRM2CHRM1 | |
| SCHEMBL811848 | 0.71 | POLB (0.51) | CHRM3CHRM2CHRM1 | |
| SCHEMBL29659945 | 0.71 | POLB (0.51) | CHRM3CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867432-B1 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | AVENTIS PHARMA GMBH (DE) | 2004-06-09 | — | — | EP | disclosed |
| US-6211196-B1 | 8-BENZYLOXY-(TETRAHYDRO)QUINOLINE DERIVATIVES; LIVER CIRRHOSIS, ALZHEIMER*S DISEASE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-04-03 | — | — | US | disclosed |
| CN-1194978-A | Benzyloxy-substituted, fused N heterocycles, process for their preparation and their use as bradykinin receptor antagonists | HOECHST AG (DE) | 1998-10-07 | — | — | CN | disclosed |
| EP-0867432-A2 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-30 | — | — | EP | disclosed |