Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5858706 | 0.88 | SLC6A3 (0.42) | SLC6A3KDM4CMEN1KMT2AL3MBTL1 | |
| SCHEMBL8782641 | 0.86 | SLC6A3 (0.46) | SLC6A3KDM4CL3MBTL1KCNA5SCN5A | |
| SCHEMBL8971968 | 0.86 | SLC6A3 (0.42) | SLC6A3KDM4CMEN1KMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL8369516 | 0.85 | SLC6A3 (0.45) | SLC6A3KDM4CL3MBTL1SLC6A2SLC6A4 | |
| SCHEMBL9053699 | 0.83 | SLC6A3 (0.44) | SLC6A3KDM4CMEN1KMT2AL3MBTL1 | |
| SCHEMBL8972640 | 0.82 | SLC6A3 (0.48) | SLC6A3KDM4CMEN1KMT2ASLC6A2 | |
| SCHEMBL6579584 | 0.82 | SLC6A3 (0.42) | SLC6A3KDM4CMEN1KMT2AL3MBTL1 | |
| SCHEMBL8706751 | 0.82 | SLC6A3 (0.48) | SLC6A3KDM4CMEN1KMT2ASLC6A2 | |
| SCHEMBL7305306 | 0.82 | SLC6A3 (0.41) | SLC6A3KDM4CMEN1KMT2AL3MBTL1 | |
| SCHEMBL8592474 | 0.81 | SLC6A3 (0.44) | SLC6A3KDM4CSLC6A2SLC6A4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994876-B1 | QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS | PFIZER LTD (GB) | 2004-09-08 | — | — | EP | disclosed |
| US-6380396-B1 | CHEMICAL INTERMEDIATES FOR ANTIINFLAMMATORY AGENTS | PFIZER INC. | 2002-04-30 | — | — | US | disclosed |
| US-6207678-B1 | USED FOR TREATING INFLAMMATORY DISEASE SUCH AS ARTHRITIS, PSORIASIS, ASTHMA OR INFLAMMATORY BOWEL DISEASE, CENTRAL NERVOUS SYSTEM DISORDER SUCH AS ANXIETY, DEPRESSION, DEMENTIA OR PSYCHOSIS, GASTROINTESTINAL DISORDERS | PFIZER INC | 2001-03-27 | — | — | US | disclosed |
| EP-0994876-A1 | QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS | Pfizer Limited (GB) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998057972-A1 | QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS | PFIZER LIMITED (GB) | 1998-12-23 | — | — | WO | disclosed |