Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 8/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28090328 | 0.86 | GPR84 (0.50) | NPC1HTTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL2955779 | 0.84 | GPR84 (0.49) | NPC1HTTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL28062636 | 0.84 | GPR84 (0.49) | NPC1HTTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL3833757 | 0.82 | LIPG (0.50) | HTTTP53MAPTTDP1L3MBTL1 | |
| SCHEMBL8720799 | 0.82 | LIPG (0.50) | HTTTP53MAPTTDP1L3MBTL1 | |
| SCHEMBL18778553 | 0.81 | GPR84 (0.44) | NPC1HTTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL3907145 | 0.80 | MAOB (0.44) | MYCMAPK14TRPV1 | |
| SCHEMBL9806810 | 0.78 | S1PR1 (0.43) | NPC1HTTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL9806788 | 0.78 | MYC (0.38) | NPC1HTTRAB9ASMN1; SMN2GAA | |
| SCHEMBL10665776 | 0.78 | S1PR1 (0.43) | NPC1HTTRAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140083-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-01-02 | — | — | EP | disclosed |
| US-6469018-B1 | INHIBITING CYTOKINES AND THE TREATMENT OF A CYTOKINE MEDIATED DISEASE, BY ADMINISTRATION OF COMPOUNDS SUCH AS:2-(4-FLUOROPHENYL)-3-(2-METHYLTHIOPYRIMIDIN-4-YL)PYRIDINE | SMITHKLINE BEECHAM CORPORATION | 2002-10-22 | — | — | US | disclosed |
| EP-1140083-A1 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040243-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |