Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.47 |
| ▸ | PARG | Q86W56 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6577807 | 0.92 | HTR6 (0.39) | HTR6PARGPTGDR2 | |
| SCHEMBL6577381 | 0.88 | HTR6 (0.48) | HTR6PARGALDH1A1SFRP1 | |
| SCHEMBL6580232 | 0.87 | HTR6 (0.48) | HTR6ALDH1A1SMN1; SMN2PTGDR2 | |
| SCHEMBL6580188 | 0.86 | HTR6 (0.45) | HTR6PARGPTGDR2 | |
| SCHEMBL6575479 | 0.80 | HTR6 (0.48) | HTR6ALDH1A1SMN1; SMN2POLBMAPT | |
| Hydrochloric Acid SCHEMBL6577375 | 0.79 | HTR6 (0.48) | HTR6ALDH1A1SMN1; SMN2POLBMAPT | |
| SCHEMBL6579555 | 0.78 | HTR6 (0.46) | HTR6ALDH1A1SMN1; SMN2POLBMAPT | |
| SCHEMBL6577344 | 0.78 | HTR6 (0.54) | HTR6SFRP1 | |
| Hydrochloric Acid SCHEMBL6575517 | 0.77 | HTR6 (0.47) | HTR6ALDH1A1SMN1; SMN2POLBMAPT | |
| SCHEMBL6575520 | 0.74 | SPR (0.46) | HTR6CNR2ALDH1A1MAPTPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411925-A1 | 5-ARYLSULFONYL INDOLES HAVING 5-HT6 RECEPTOR AFFINITY | PHARMACIA & UPJOHN COMPANY (US) | 2004-04-28 | — | — | EP | claimed |
| WO-2003011284-A1 | 5-ARYLSULFONYL INDOLES HAVING 5-HT6 RECEPTOR AFFINITY | PHARMACIA & UPJOHN COMPANY (US) | 2003-02-13 | — | — | WO | claimed |
| EP-1411925-A1 | 5-ARYLSULFONYL INDOLES HAVING 5-HT6 RECEPTOR AFFINITY | PHARMACIA & UPJOHN COMPANY (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003011284-A1 | 5-ARYLSULFONYL INDOLES HAVING 5-HT6 RECEPTOR AFFINITY | PHARMACIA & UPJOHN COMPANY (US) | 2003-02-13 | — | — | WO | disclosed |