Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | S100A4 | P26447 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | CTSV | O60911 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | KRAS | P01116 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6579521 | 1.00 | TOP1 (0.40) | TOP1HTTALDH1A1PTGS2LMNA | |
| SCHEMBL6577098 | 0.91 | MAPT (0.38) | TOP1HTTALDH1A1PTGS2LMNA | |
| SCHEMBL6577091 | 0.91 | MAPT (0.38) | TOP1HTTALDH1A1PTGS2LMNA | |
| SCHEMBL6582135 | 0.85 | CNR1 (0.39) | HTTALDH1A1LMNACYP1A2MAPT | |
| SCHEMBL6582132 | 0.85 | CNR1 (0.39) | HTTALDH1A1LMNACYP1A2MAPT | |
| SCHEMBL7988582 | 0.82 | ALDH1A1 (0.45) | TOP1HTTALDH1A1LMNACYP1A2 | |
| SCHEMBL6579909 | 0.79 | CYP1A2 (0.51) | HTTLMNACYP1A2MAPTTDP1 | |
| SCHEMBL6582308 | 0.77 | MAPT (0.47) | HTTALDH1A1LMNACYP1A2MAPT | |
| SCHEMBL8004065 | 0.75 | KDM4E (0.44) | ALDH1A1LMNACYP1A2MAPTTDP1 | |
| SCHEMBL7988381 | 0.74 | HTT (0.42) | TOP1HTTALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927718-B1 | Quinolinone derivative, method for preparing the same, and anti-allergic agent | DAINIPPON INK & CHEMICALS (JP) | 2004-02-25 | — | — | EP | disclosed |
| US-6271416-B1 | O-(HYDROCARBONOXYACETAMIDO)BENZOIC ACID DERIVATIVES AS INTERMEDIATES | DAINIPPON INK AND CHEMICALS, INC. (JP) | 2001-08-07 | — | — | US | disclosed |
| US-6136822-A | ETHER, HYDROXY QUINOLINONE COMPOUNDS | DAINIPPON INK AND CHEMICALS, INC. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-0927718-A1 | Quinolinone derivative, method for preparing the same, and anti-allergic agent | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1999-07-07 | — | — | EP | disclosed |