SCHEMBL6579531

SCHEMBL6579531

Cc1cc(C)cc(C(=O)c2nccn2CC(CCOS(C)(=O)=O)c2ccc(Cl)c(Cl)c2)c1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.34
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32
PKM P14618 1/20 0.32
CYP2C19 P33261 1/20 0.32
TACR2 P21452 1/20 0.32
S1PR3 Q99500 3/20 0.32
S1PR2 O95136 2/20 0.32
S1PR4 O95977 2/20 0.32
WDR5 P61964 1/20 0.32
S1PR1 P21453 1/20 0.31
CA12 O43570 2/20 0.31
CA1 P00915 2/20 0.31
CA2 P00918 2/20 0.31
CA3 P07451 2/20 0.31
CA4 P22748 2/20 0.31
CA6 P23280 2/20 0.31
CA5A P35218 2/20 0.31
CA7 P43166 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6582482 0.88 LDHA (0.33) HTTCYP1A2CYP3A4CYP2C9PKM
SCHEMBL6579767 0.88 TDP1 (0.32) HTTTACR2S1PR3S1PR2S1PR4
SCHEMBL6579685 0.86 HTT (0.34) HTTTACR2S1PR3S1PR2S1PR4
SCHEMBL6579456 0.84 S1PR3 (0.36) HTTCYP1A2CYP3A4CYP2C9PKM
SCHEMBL6582820 0.83 ESRRA (0.35) CYP3A4TACR2NPSR1
SCHEMBL6579201 0.80 HCRTR2 (0.33) TACR2LMNASMN1; SMN2ALDH1A1
SCHEMBL6579663 0.80 HCRTR2 (0.33) TACR2LMNASMN1; SMN2ALDH1A1
SCHEMBL6576781 0.77 OPRD1 (0.35) TACR2OPRD1OPRK1
SCHEMBL6581521 0.73 UTS2R (0.38) HTTSMN1; SMN2ALDH1A1
SCHEMBL6579701 0.73 MCHR1 (0.35) TACR2WDR5OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0994876-B1 QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS PFIZER LTD (GB) 2004-09-08 EP disclosed
US-6380396-B1 CHEMICAL INTERMEDIATES FOR ANTIINFLAMMATORY AGENTS PFIZER INC. 2002-04-30 US disclosed
US-6207678-B1 USED FOR TREATING INFLAMMATORY DISEASE SUCH AS ARTHRITIS, PSORIASIS, ASTHMA OR INFLAMMATORY BOWEL DISEASE, CENTRAL NERVOUS SYSTEM DISORDER SUCH AS ANXIETY, DEPRESSION, DEMENTIA OR PSYCHOSIS, GASTROINTESTINAL DISORDERS PFIZER INC 2001-03-27 US disclosed
EP-0994876-A1 QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS Pfizer Limited (GB) 2000-04-26 EP disclosed
WO-1998057972-A1 QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS PFIZER LIMITED (GB) 1998-12-23 WO disclosed