SCHEMBL6582482

SCHEMBL6582482

CS(=O)(=O)OCCC(Cn1ccnc1C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LDHA P00338 2/20 0.33
LDHB P07195 2/20 0.33
MCL1 Q07820 2/20 0.33
BCL2L1 Q07817 1/20 0.33
HTT P42858 1/20 0.33
TACR2 P21452 8/20 0.32
TACR1 P25103 8/20 0.32
MCHR1 Q99705 1/20 0.32
OPRD1 P41143 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32
PKM P14618 1/20 0.32
CYP2C19 P33261 1/20 0.32
S1PR3 Q99500 1/20 0.32
WDR5 P61964 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
LMNA P02545 1/20 0.31
TP53 P04637 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6579531 0.88 HTT (0.34) HTTTACR2OPRD1CYP1A2CYP3A4
SCHEMBL6579456 0.87 S1PR3 (0.36) HTTCYP1A2CYP3A4CYP2C9PKM
SCHEMBL6579701 0.86 MCHR1 (0.35) LDHALDHBTACR2TACR1MCHR1
SCHEMBL6582820 0.80 ESRRA (0.35) MCL1BCL2L1TACR2TACR1CYP3A4
SCHEMBL6579663 0.77 HCRTR2 (0.33) TACR2L3MBTL1LMNA
SCHEMBL6579201 0.77 HCRTR2 (0.33) TACR2L3MBTL1LMNA
SCHEMBL6579767 0.76 TDP1 (0.32) LDHALDHBHTTTACR2S1PR3
Hydrochloric Acid SCHEMBL6577521 0.76 OPRD1 (0.40) TACR2TACR1OPRD1
SCHEMBL6579685 0.74 HTT (0.34) LDHALDHBHTTTACR2OPRD1
SCHEMBL6579045 0.71 RORC (0.41) TACR2MCHR1WDR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0994876-B1 QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS PFIZER LTD (GB) 2004-09-08 EP disclosed
US-6380396-B1 CHEMICAL INTERMEDIATES FOR ANTIINFLAMMATORY AGENTS PFIZER INC. 2002-04-30 US disclosed
US-6207678-B1 USED FOR TREATING INFLAMMATORY DISEASE SUCH AS ARTHRITIS, PSORIASIS, ASTHMA OR INFLAMMATORY BOWEL DISEASE, CENTRAL NERVOUS SYSTEM DISORDER SUCH AS ANXIETY, DEPRESSION, DEMENTIA OR PSYCHOSIS, GASTROINTESTINAL DISORDERS PFIZER INC 2001-03-27 US disclosed