Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BRS3 | P32247 | 3/20 | 0.39 |
| ▸ | EDNRA | P25101 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582681 | 0.97 | KDM4E (0.40) | SMN1; SMN2ALDH1A1KDM4EHPGDBRS3 | |
| SCHEMBL6580281 | 0.89 | KDM4E (0.39) | SMN1; SMN2ALDH1A1KDM4EHPGDBRS3 | |
| SCHEMBL6579920 | 0.88 | EDNRA (0.46) | SMN1; SMN2ALDH1A1KDM4EHPGDBRS3 | |
| SCHEMBL7506638 | 0.88 | EDNRA (0.45) | SMN1; SMN2ALDH1A1KDM4EHPGDBRS3 | |
| SCHEMBL6580198 | 0.86 | EDNRA (0.44) | SMN1; SMN2ALDH1A1KDM4EHPGDEDNRA | |
| SCHEMBL8524654 | 0.86 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1KDM4EHPGDBRS3 | |
| SCHEMBL7501556 | 0.85 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1KDM4EHPGDBRS3 | |
| SCHEMBL6588042 | 0.84 | BRS3 (0.40) | SMN1; SMN2ALDH1A1KDM4EHPGDBRS3 | |
| SCHEMBL7495951 | 0.81 | EDNRA (0.46) | SMN1; SMN2ALDH1A1KDM4EHPGDBRS3 | |
| SCHEMBL7494883 | 0.80 | EDNRA (0.46) | SMN1; SMN2ALDH1A1KDM4EHPGDBRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804435-B1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2004-03-10 | — | — | EP | claimed |