Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6580281 | 0.93 | KDM4E (0.39) | SMN1; SMN2KDM4EALDH1A1HPGDBRS3 | |
| SCHEMBL7501396 | 0.89 | EDNRA (0.45) | SMN1; SMN2KDM4EALDH1A1HPGDBRS3 | |
| SCHEMBL7499196 | 0.87 | EDNRA (0.45) | SMN1; SMN2KDM4EALDH1A1HPGDBRS3 | |
| SCHEMBL8434942 | 0.85 | BRS3 (0.42) | SMN1; SMN2KDM4EALDH1A1HPGDBRS3 | |
| SCHEMBL6579951 | 0.85 | SMN1; SMN2 (0.41) | SMN1; SMN2KDM4EALDH1A1HPGDBRS3 | |
| SCHEMBL6580022 | 0.83 | BRS3 (0.43) | SMN1; SMN2KDM4EALDH1A1HPGDBRS3 | |
| SCHEMBL6582681 | 0.83 | KDM4E (0.40) | SMN1; SMN2KDM4EALDH1A1HPGDBRS3 | |
| SCHEMBL6580278 | 0.83 | EDNRA (0.45) | SMN1; SMN2KDM4EALDH1A1HPGDEDNRA | |
| SCHEMBL8434873 | 0.82 | EDNRA (0.45) | SMN1; SMN2KDM4EALDH1A1HPGDBRS3 | |
| SCHEMBL8323946 | 0.81 | EDNRB (0.40) | SMN1; SMN2KDM4EALDH1A1HPGDBRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0776325-B1 | NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2002-11-20 | — | — | EP | claimed |