Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 3/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6577406 | 0.96 | PTPN1 (0.40) | PTPN1NPC1MAPTRAB9APDE4B | |
| SCHEMBL6579597 | 0.80 | PDE4B (0.34) | PTPN1PDE4BCA12CA1CA9 | |
| SCHEMBL17543559 | 0.78 | PTPN1 (0.34) | PTPN1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6582078 | 0.78 | PDE4B (0.38) | PTPN1PDE4B | |
| SCHEMBL17542911 | 0.78 | PTPN1 (0.34) | PTPN1PDE4BHTR2A | |
| SCHEMBL12559624 | 0.74 | ADRA2A (0.41) | MAPTPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6581115 | 0.72 | ADRB3 (0.37) | PDE4BPDE4APDE4CPDE4DADRA2A | |
| SCHEMBL6867371 | 0.71 | ALDH1A1 (0.56) | PTPN1MAPTCA12CA1CA9 | |
| SCHEMBL6582027 | 0.71 | PTGS1 (0.37) | PDE4BPDE4APDE4CPDE4DHTR2C | |
| SCHEMBL7851986 | 0.69 | PTPN1 (0.43) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005458-B1 | CARBOSTYRIL DERIVATIVES FOR INHIBITING SKIN ERYTHEMA AND/OR SKIN PIGMENTATION | OTSUKA PHARMA CO LTD (JP) | 2004-10-13 | — | — | EP | disclosed |
| US-6133264-A | Carbostyril derivatives for inhibiting skin erythema and/or skin pigmentation | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2000-10-17 | — | — | US | disclosed |