Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 4/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | FDPS | P14324 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28374740 | 0.80 | SLC6A2 (0.54) | CYP2C19CYP1A2CYP2C9SLC6A2TAAR1 | |
| SCHEMBL6552343 | 0.80 | SLC6A2 (0.54) | CYP2C19CYP1A2CYP2C9SLC6A2TAAR1 | |
| SCHEMBL11211304 | 0.78 | CYP2C19 (0.61) | CYP2C19CYP1A2CYP2C9SLC6A2TAAR1 | |
| SCHEMBL3583487 | 0.78 | CYP2C19 (0.61) | CYP2C19CYP1A2CYP2C9SLC6A2TAAR1 | |
| SCHEMBL6048465 | 0.78 | CYP2C19 (0.42) | CYP2C19CYP1A2CYP2C9TAAR1LMNA | |
| SCHEMBL6435187 | 0.77 | CYP2C9 (0.59) | CYP2C19CYP1A2CYP2C9SLC6A2TAAR1 | |
| SCHEMBL1698269 | 0.76 | SLC6A2 (0.67) | CYP2C19CYP1A2CYP2C9SLC6A2TAAR1 | |
| SCHEMBL16626128 | 0.75 | TAAR1 (0.48) | CYP2C19CYP1A2CYP2C9SLC6A2TAAR1 | |
| SCHEMBL15380148 | 0.75 | CYP2C19 (0.57) | CYP2C19CYP1A2CYP2C9SLC6A2TAAR1 | |
| SCHEMBL21353 | 0.75 | SLC6A2 (0.58) | CYP2C19CYP1A2CYP2C9SLC6A2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040236118-A1 | Pyrrolidine derivatives and method of synthesizing these | EIZAI CO., LTD (JP) | 2004-11-25 | — | — | US | disclosed |
| EP-1413574-A1 | PYRROLIDINE DERIVATIVES AND METHOD OF SYNTHESIZING THESE | Eizai Co., Ltd. (JP) | 2004-04-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040236118-A1 | Pyrrolidine derivatives and method of synthesizing these | ADH1C, ADH5, ADH1A | CYP2C19 1076/4885CYP1A2 317/4885CYP2C9 1214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.