SCHEMBL6580164

SCHEMBL6580164

Clc1cc2c(cc1Cn1cnc(Br)c1Br)OCO2

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 1/20 0.48
HSP90AA1 P07900 6/20 0.39
HSP90B1 P14625 5/20 0.39
TRAP1 Q12931 5/20 0.39
CRHBP P24387 1/20 0.39
CRHR2 Q13324 1/20 0.39
SLC22A12 Q96S37 1/20 0.39
PDE5A O76074 1/20 0.37
OPRM1 P35372 2/20 0.36
DRD3 P35462 2/20 0.36
OPRD1 P41143 2/20 0.36
OPRK1 P41145 2/20 0.36
OPRL1 P41146 2/20 0.36
CACNA1F O60840 1/20 0.36
CACNA1D Q01668 1/20 0.36
CACNA1S Q13698 1/20 0.36
CACNA1C Q13936 1/20 0.36
SIGMAR1 Q99720 1/20 0.36
P2RX7 Q99572 1/20 0.35
MEN1 O00255 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6580193 0.84 ADORA2A (0.41) ADORA2AHSP90AA1HSP90B1TRAP1CRHBP
SCHEMBL3392282 0.74 ADORA2A (0.68) ADORA2AHSP90AA1HSP90B1TRAP1
SCHEMBL3834423 0.73 HSP90AA1 (0.43) ADORA2AHSP90AA1HSP90B1TRAP1CRHBP
SCHEMBL7501419 0.72 KCNH2 (0.44) ADORA2ASLC22A12P2RX7MEN1KMT2A
SCHEMBL7503934 0.71 HSP90AA1 (0.41) ADORA2AHSP90AA1HSP90B1TRAP1CRHBP
SCHEMBL8664779 0.70 BRS3 (0.51) ADORA2ASLC22A12PDE5AALDH1A1HPGD
SCHEMBL3834411 0.70 HSP90AA1 (0.42) ADORA2AHSP90AA1HSP90B1TRAP1CRHBP
SCHEMBL6161550 0.70 CYP2D6 (0.53) ADORA2ASLC22A12P2RX7SMN1; SMN2
SCHEMBL11013613 0.69 CYP19A1 (0.50) MAPT
SCHEMBL6159202 0.69 KCNH2 (0.48) ADORA2AHSP90AA1HSP90B1SLC22A12P2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0804435-B1 NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AVENTIS PHARMA SA (FR) 2004-03-10 EP disclosed
US-5856509-A HYPOTENSIVE AGENTS ROUSSEL UCLAF (FR) 1999-01-05 US disclosed
EP-0804435-A1 NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME ROUSSEL UCLAF (FR) 1997-11-05 EP disclosed
WO-1996004275-A1 NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME ROUSSEL UCLAF (FR) 1996-02-15 WO disclosed