Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6161550 | 0.82 | CYP2D6 (0.53) | KCNH2LMNASLC22A12P2RX7ADORA2A | |
| SCHEMBL6159202 | 0.81 | KCNH2 (0.48) | KCNH2SLC22A12P2RX7ADORA2A | |
| SCHEMBL6582037 | 0.80 | BRD4 (0.45) | SLC22A12ADORA2AMEN1KMT2A | |
| SCHEMBL1349924 | 0.75 | TP53 (0.40) | LMNASLC22A12ADORA2AMEN1KMT2A | |
| SCHEMBL27541363 | 0.75 | LMNA (0.50) | KCNH2LMNAL3MBTL1 | |
| SCHEMBL27576220 | 0.75 | LMNA (0.57) | KCNH2LMNAL3MBTL1KMT2A | |
| SCHEMBL28245281 | 0.75 | KCNH2 (0.55) | KCNH2LMNAL3MBTL1P2RX7 | |
| SCHEMBL27542855 | 0.72 | KCNH2 (0.48) | KCNH2LMNAL3MBTL1P2RX7 | |
| SCHEMBL27535901 | 0.72 | LMNA (0.48) | KCNH2LMNAL3MBTL1 | |
| SCHEMBL27541318 | 0.72 | LMNA (0.48) | KCNH2LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0776325-B1 | NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2002-11-20 | — | — | EP | disclosed |
| US-5932741-A | TREATING ILLNESSES RESULTING FROM ABNORMAL STIMULATION OF ENDOTHELIN RECEPTORS | HOECHST MARION ROUSSEL (FR) | 1999-08-03 | — | — | US | disclosed |
| US-5811444-A | IMIDAZOLE DERIVATIVES | ROUSSEL UCLAF (FR) | 1998-09-22 | — | — | US | disclosed |
| EP-0776325-A1 | NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ROUSSEL UCLAF (FR) | 1997-06-04 | — | — | EP | disclosed |
| WO-1996004276-A1 | NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ROUSSEL UCLAF (FR) | 1996-02-15 | — | — | WO | disclosed |