SCHEMBL6580193

SCHEMBL6580193

O=Cc1c(Br)ncn1Cc1cc2c(cc1Cl)OCO2

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 1/20 0.41
SLC22A12 Q96S37 1/20 0.40
PDE5A O76074 1/20 0.35
HSP90AA1 P07900 7/20 0.35
OPRM1 P35372 3/20 0.35
OPRD1 P41143 3/20 0.35
OPRK1 P41145 3/20 0.35
DRD3 P35462 2/20 0.35
OPRL1 P41146 2/20 0.35
CACNA1F O60840 1/20 0.35
CACNA1D Q01668 1/20 0.35
CACNA1S Q13698 1/20 0.35
CACNA1C Q13936 1/20 0.35
SIGMAR1 Q99720 1/20 0.35
P2RX7 Q99572 1/20 0.34
HSP90B1 P14625 5/20 0.34
TRAP1 Q12931 5/20 0.34
MCHR1 Q99705 1/20 0.33
KDM4E B2RXH2 2/20 0.33
ALDH1A1 P00352 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6580164 0.84 ADORA2A (0.48) ADORA2ASLC22A12PDE5AHSP90AA1OPRM1
SCHEMBL7505827 0.76 HSP90AA1 (0.39) ADORA2ASLC22A12HSP90AA1OPRM1OPRD1
SCHEMBL3834411 0.74 HSP90AA1 (0.42) ADORA2ASLC22A12HSP90AA1OPRM1OPRD1
SCHEMBL6160770 0.73 HSP90AA1 (0.38) SLC22A12HSP90AA1OPRM1OPRD1OPRK1
SCHEMBL6580573 0.72 BRS3 (0.42) SLC22A12PDE5ASMN1; SMN2
SCHEMBL6164112 0.72 EDNRA (0.49) SLC22A12HSP90AA1OPRM1OPRD1OPRK1
SCHEMBL3838481 0.72 HSP90AA1 (0.37) HSP90AA1OPRM1OPRD1OPRK1DRD3
SCHEMBL6579996 0.71 HSP90AA1 (0.38) SLC22A12HSP90AA1OPRM1OPRD1OPRK1
SCHEMBL27462057 0.71 HSP90AA1 (0.39) ADORA2ASLC22A12HSP90AA1HSP90B1TRAP1
SCHEMBL7499501 0.70 ALDH1A1 (0.43) SLC22A12HSP90AA1HSP90B1TRAP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0804435-B1 NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AVENTIS PHARMA SA (FR) 2004-03-10 EP disclosed
CN-1083838-C Nvel imidazole derivatives, method for preparing same, novel intermediates thus obtained, medicinal applications of same and pharmaceutical compositions containing same ROUSSEL UCLEF (FR) 2002-05-01 CN disclosed
US-5856509-A HYPOTENSIVE AGENTS ROUSSEL UCLAF (FR) 1999-01-05 US disclosed
EP-0804435-A1 NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME ROUSSEL UCLAF (FR) 1997-11-05 EP disclosed
CN-1159805-A Nvel imidazole derivatives, method for preparing same, novel intermediates thus obtained, medicinal applications of same and pharmaceutical compositions containing same ROUSSEL UCLAF (FR) 1997-09-17 CN disclosed
WO-1996004275-A1 NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME ROUSSEL UCLAF (FR) 1996-02-15 WO disclosed