Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 9/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313813 | 0.80 | VCAM1 (0.56) | VCAM1TDP1RAB9ATSHRMAPK1 | |
| SCHEMBL6576203 | 0.78 | TDP1 (0.60) | VCAM1TDP1TSHRMAPK1ALDH1A1 | |
| SCHEMBL272708 | 0.78 | TDP1 (0.60) | VCAM1TDP1RAB9ATSHRMAPK1 | |
| SCHEMBL6581274 | 0.78 | ALDH1A1 (0.41) | TDP1RAB9AMAPK1ALDH1A1HPGD | |
| SCHEMBL6581238 | 0.76 | VCAM1 (0.51) | VCAM1TDP1RAB9ATSHRMAPK1 | |
| SCHEMBL28571587 | 0.76 | VCAM1 (0.51) | VCAM1TDP1RAB9ATSHRMAPK1 | |
| SCHEMBL278628 | 0.75 | TDP1 (0.60) | VCAM1TDP1TSHRMAPK1ALDH1A1 | |
| SCHEMBL894816 | 0.75 | TDP1 (0.60) | VCAM1TDP1RAB9ATSHRMAPK1 | |
| SCHEMBL30583791 | 0.75 | TDP1 (0.60) | VCAM1TDP1RAB9ATSHRMAPK1 | |
| Hydroxyamine SCHEMBL6264479 | 0.74 | TDP1 (0.55) | VCAM1TDP1RAB9ATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867432-B1 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | AVENTIS PHARMA GMBH (DE) | 2004-06-09 | — | — | EP | disclosed |
| US-6211196-B1 | 8-BENZYLOXY-(TETRAHYDRO)QUINOLINE DERIVATIVES; LIVER CIRRHOSIS, ALZHEIMER*S DISEASE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-04-03 | — | — | US | disclosed |
| EP-0867432-A2 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-30 | — | — | EP | disclosed |