Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 2/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21819347 | 0.88 | GPR119 (0.55) | S1PR2SMN1; SMN2LMNAMAPTKMT2A | |
| SCHEMBL21819487 | 0.87 | KMT2A (0.64) | SMN1; SMN2LMNAMAPTKMT2AALDH1A1 | |
| SCHEMBL6785203 | 0.87 | CYP2D6 (0.62) | S1PR2SMN1; SMN2LMNAMAPTKMT2A | |
| SCHEMBL13872055 | 0.82 | KMT2A (0.68) | S1PR2SMN1; SMN2LMNAMAPTKMT2A | |
| SCHEMBL21819310 | 0.81 | KMT2A (0.54) | S1PR2SMN1; SMN2LMNAMAPTKMT2A | |
| SCHEMBL7502665 | 0.78 | STS (0.53) | SMN1; SMN2LMNAKMT2AMEN1CYP2C19 | |
| SCHEMBL28089023 | 0.77 | KMT2A (0.58) | S1PR2SMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL3216576 | 0.76 | HPGDS (0.54) | MAPTALDH1A1KDM4EPKM | |
| SCHEMBL29268519 | 0.75 | SMN1; SMN2 (0.67) | S1PR2SMN1; SMN2LMNAMAPTKMT2A | |
| SCHEMBL21819472 | 0.73 | STS (0.52) | SMN1; SMN2MAPTKMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060175-B1 | TRYPTASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2004-11-17 | — | — | EP | disclosed |
| US-6613769-B1 | Incubating samples with enzyme inhibitors, then determining complexes formed; medical diagnosis; therapy for allergies and inflammation | Max-Planck-Gesellschaft zur Föderung der Wissenschaften. e.V. (DE) | 2003-09-02 | — | — | US | disclosed |
| US-6489327-B1 | TREATING A DISEASE SUSCEPTIBLE TO TRYPTASE INHIBITION SUCH AS ASTHMA, INFLAMMATORY BOWEL DISEASE, PSORIASIS OR RHINITIS | MAX-PLANCK-GESELLSCHAFT ZUR FORDRUNGDER WISENSCHAFTEN, E.V. (DE) | 2002-12-03 | — | — | US | disclosed |
| EP-1060175-A2 | TRYPTASE INHIBITORS | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2000-12-20 | — | — | EP | disclosed |
| EP-1060171-A2 | TRYPTASE INHIBITORS | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999040083-A2 | BIFUNCTIONAL TRYPTASE INHIBITORS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 1999-08-12 | — | — | WO | disclosed |
| WO-1999040073-A2 | TRYPTASE INHIBITORS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 1999-08-12 | — | — | WO | disclosed |