Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 3/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584115 | 0.86 | TRPV1 (0.47) | BCHEACHEMAOBCHRM3NPC1 | |
| SCHEMBL6581748 | 0.86 | BCHE (0.50) | BCHEACHEMAOBCHRM3NPC1 | |
| SCHEMBL6586747 | 0.77 | HRH1 (0.50) | BCHEACHEHRH1 | |
| SCHEMBL7416499 | 0.77 | CCR3 (0.53) | CHRM3CCR3HTT | |
| SCHEMBL6672269 | 0.77 | RAB9A (0.61) | MAPK1NPC1RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL8661228 | 0.75 | CTSK (0.51) | NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL6586884 | 0.74 | BCHE (0.43) | BCHEACHEMAOBALDH1A1L3MBTL1 | |
| SCHEMBL5221853 | 0.72 | MAPK1 (0.46) | BCHEACHEMAOBCHRM3MAPK1 | |
| SCHEMBL8591719 | 0.70 | CHRM3 (0.55) | CHRM3NPC1RAB9A | |
| SCHEMBL23137089 | 0.68 | ATM (0.49) | MAPK1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815080-B1 | DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT4 ANTAGONISTIC ACTIVITY | BOEHRINGER INGELHEIM ITALIA (IT) | 2004-06-16 | — | — | EP | disclosed |
| US-6002009-A | Di-substituted 1,4-piperidine esters and amides having 5-HT4 antagonistic activity | BOEHRINGER INGELHEIM ITALIA, S.P.A. (IT) | 1999-12-14 | — | — | US | disclosed |
| WO-1996028424-A1 | DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT4 ANTAGONISTIC ACTIVITY | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1996-09-19 | — | — | WO | disclosed |