Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR3 | O60755 | 3/20 | 0.56 |
| ▸ | NR2F2 | P24468 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | TNF | P01375 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | AGER | Q15109 | 1/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29770318 | 0.88 | KCNH2 (0.56) | GALR3NR2F2RAB9ANPC1TNF | |
| SCHEMBL13035832 | 0.82 | TNF (0.57) | GALR3NR2F2RAB9ANPC1TNF | |
| SCHEMBL16116733 | 0.79 | PRKACA (0.57) | GALR3NR2F2RAB9ANPC1TNF | |
| SCHEMBL6446137 | 0.77 | LMNA (0.69) | GALR3NR2F2RAB9ANPC1TNF | |
| SCHEMBL1104819 | 0.75 | TNF (0.66) | GALR3NR2F2RAB9ANPC1TNF | |
| SCHEMBL31498004 | 0.74 | TNF (0.64) | GALR3NR2F2RAB9ANPC1TNF | |
| Hydrochloric Acid SCHEMBL8009001 | 0.74 | PKM (0.64) | GALR3NR2F2RAB9ANPC1TNF | |
| SCHEMBL4728183 | 0.74 | TNF (0.64) | GALR3NR2F2RAB9ANPC1TNF | |
| SCHEMBL4191641 | 0.74 | TNF (0.64) | GALR3NR2F2RAB9ANPC1TNF | |
| SCHEMBL11130492 | 0.74 | TNF (0.64) | GALR3NR2F2RAB9ANPC1TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1075471-B1 | INDOLYL DERIVATIVES AS SEROTONERGIC AGENTS | WYETH CORP (US) | 2004-11-17 | — | — | EP | disclosed |
| US-6204274-B1 | TREAT CENTRAL NERVOUS SYSTEM DISORDERS, SUCH AS DEPRESSION AND ANXIETY AND OTHER CONDITIONS FOR WHICH SEROTONIN REUPTAKE INHIBITORS ARE USED. | AMERICAN HOME PRODUCTS CORPORATION | 2001-03-20 | — | — | US | disclosed |
| EP-1075471-A1 | INDOLYL DERIVATIVES AS SEROTONERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-14 | — | — | EP | disclosed |
| WO-1999055694-A1 | INDOLYL DERIVATIVES AS SEROTONERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-04 | — | — | WO | disclosed |