Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.39 |
| ▸ | PDE2A | O00408 | 10/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6377580 | 0.90 | PDE3B (0.42) | CYP1A2PDE10APDE2A | |
| SCHEMBL5420165 | 0.88 | PDE3B (0.44) | CYP1A2PDE10APDE2ATP53 | |
| SCHEMBL6585534 | 0.85 | PDE10A (0.43) | CYP1A2PDE10APDE2ATP53GAA | |
| SCHEMBL6584270 | 0.81 | PDE2A (0.44) | CYP1A2PDE10APDE2ATP53GAA | |
| SCHEMBL5424244 | 0.80 | PDE3B (0.45) | CYP1A2PDE10APDE2A | |
| SCHEMBL5420162 | 0.79 | PPARG (0.43) | PDE2ATP53 | |
| SCHEMBL7719001 | 0.78 | CYP1A2 (0.39) | CYP1A2PDE10APDE2ATP53GAA | |
| SCHEMBL6618378 | 0.77 | CYP3A4 (0.44) | CYP1A2PDE10APDE2ATP53GAA | |
| SCHEMBL6583523 | 0.77 | APLNR (0.47) | CYP1A2PDE10APDE2A | |
| SCHEMBL5412722 | 0.77 | PDE3B (0.43) | CYP1A2PDE10APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404656-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING MICROGLIA-ACTIVATION ASSOCIATED DISEASES SUCH AS INFLAMMATORY, ALLERGIC, INFECTIOUS OR AUTOIMMUNE DISEASES | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003006438-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING MICROGLIA-ACTIVATION ASSOCIATED DISEASES SUCH AS INFLAMMATORY, ALLERGIC, INFECTIOUS OR AUTOIMMUNE DISEASES | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-01-23 | — | — | WO | disclosed |