Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6369243 | 0.89 | PPARG (0.44) | PDE10ACYP1A2PDE2A | |
| SCHEMBL5417434 | 0.87 | PDE3B (0.44) | PDE10ACYP1A2PDE2AACSS2 | |
| SCHEMBL6581776 | 0.85 | CYP1A2 (0.39) | PDE10ACYP1A2FGFR1TP53MAPT | |
| SCHEMBL6584411 | 0.78 | PDE10A (0.44) | PDE10ACYP1A2FGFR1TP53MAPT | |
| SCHEMBL6584270 | 0.78 | PDE2A (0.44) | PDE10ACYP1A2FGFR1TP53MAPT | |
| SCHEMBL6377580 | 0.78 | PDE3B (0.42) | PDE10ACYP1A2PDE2A | |
| SCHEMBL6583694 | 0.77 | LMNA (0.44) | PDE10ACYP1A2MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5420162 | 0.77 | PPARG (0.43) | TP53PDE2A | |
| SCHEMBL7717836 | 0.76 | PDE10A (0.51) | PDE10ACYP1A2FGFR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6618378 | 0.75 | CYP3A4 (0.44) | PDE10ACYP1A2TP53MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404656-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING MICROGLIA-ACTIVATION ASSOCIATED DISEASES SUCH AS INFLAMMATORY, ALLERGIC, INFECTIOUS OR AUTOIMMUNE DISEASES | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003006438-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING MICROGLIA-ACTIVATION ASSOCIATED DISEASES SUCH AS INFLAMMATORY, ALLERGIC, INFECTIOUS OR AUTOIMMUNE DISEASES | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-01-23 | — | — | WO | disclosed |