Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7501419 | 0.80 | KCNH2 (0.44) | SLC22A12ADORA2AMEN1KMT2A | |
| SCHEMBL11570953 | 0.80 | BRD4 (0.45) | BRD4ESR1HSD17B10MEN1KMT2A | |
| SCHEMBL1349924 | 0.80 | TP53 (0.40) | SLC22A12ADORA2ACACNA1FOPRM1DRD3 | |
| SCHEMBL6161550 | 0.74 | CYP2D6 (0.53) | SLC22A12ADORA2A | |
| SCHEMBL6582630 | 0.74 | MEN1 (0.40) | SLC22A12CACNA1FOPRM1DRD3OPRD1 | |
| SCHEMBL6159202 | 0.73 | KCNH2 (0.48) | SLC22A12ADORA2A | |
| SCHEMBL9057464 | 0.73 | SMN1; SMN2 (0.57) | CACNA1FOPRM1DRD3OPRD1OPRK1 | |
| SCHEMBL17621 | 0.73 | HSD17B10 (0.62) | BRD4ESR1HSD17B10MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL233781 | 0.72 | HSD17B10 (0.60) | BRD4ESR1HSD17B10MEN1KMT2A | |
| Iodide SCHEMBL28519464 | 0.72 | HSD17B10 (0.60) | BRD4ESR1HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804435-B1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2004-03-10 | — | — | EP | disclosed |
| US-5856509-A | HYPOTENSIVE AGENTS | ROUSSEL UCLAF (FR) | 1999-01-05 | — | — | US | disclosed |
| EP-0804435-A1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ROUSSEL UCLAF (FR) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996004275-A1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ROUSSEL UCLAF (FR) | 1996-02-15 | — | — | WO | disclosed |