Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6161550 | 0.82 | CYP2D6 (0.53) | ADORA2ACYP2D6CYP2C19TSHRHIF1A | |
| SCHEMBL6582037 | 0.80 | BRD4 (0.45) | TP53THRBADORA2AOPRM1OPRD1 | |
| SCHEMBL7501419 | 0.75 | KCNH2 (0.44) | ADORA2AKMT2AMEN1SLC22A12LMNA | |
| SCHEMBL5852468 | 0.72 | CYP1A2 (0.56) | CYP2D6CYP2C19KMT2AMEN1CYP1A2 | |
| SCHEMBL6159202 | 0.71 | KCNH2 (0.48) | ADORA2ASLC22A12 | |
| SCHEMBL6577691 | 0.68 | MEN1 (0.43) | TP53KMT2AMEN1ALDH1A1NPSR1 | |
| SCHEMBL1349653 | 0.67 | KMT2A (0.45) | SIGMAR1CYP2D6CYP2C19KMT2ACYP1A2 | |
| SCHEMBL1349511 | 0.67 | CYP11B1 (0.45) | CYP2D6CYP2C19KMT2ACYP1A2LMNA | |
| SCHEMBL1347052 | 0.67 | CYP1A2 (0.70) | OPRD1OPRK1SIGMAR1CYP2D6CYP2C19 | |
| SCHEMBL1347141 | 0.67 | ALDH1A1 (0.48) | TP53OPRM1OPRK1DRD3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063090-B2 | Mineralocorticoid receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2011-11-22 | — | — | US | claimed |
| US-20100069452-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2010-03-18 | — | — | US | claimed |
| US-8063090-B2 | Mineralocorticoid receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2011-11-22 | — | — | US | disclosed |
| US-8063090-B2 | Mineralocorticoid receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2011-11-22 | — | — | US | disclosed |
| US-8063090-B2 | Mineralocorticoid receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2011-11-22 | — | — | US | disclosed |
| US-20100069452-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2010-03-18 | — | — | US | disclosed |
| US-20100069452-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2010-03-18 | — | — | US | disclosed |
| US-20100069452-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2010-03-18 | — | — | US | disclosed |
| EP-2139489-A2 | MINERALOCORTICOID RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008118319-A2 | MINERALOCORTICOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2008-10-02 | — | — | WO | disclosed |
| WO-2008118319-A2 | MINERALOCORTICOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069452-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | NR3C2, MC2R, NR3C1 | TP53 4852/4885THRB 129/4885ADORA2A 629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.