Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 8/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.33 |
| ▸ | PDE5A | O76074 | 4/20 | 0.33 |
| ▸ | PDE7B | Q9NP56 | 3/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 5/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587508 | 0.96 | PDK2 (0.34) | PDK2ALDH1A1KMT2AMEN1HTT | |
| SCHEMBL6585907 | 0.94 | PDK2 (0.33) | PDK2ALDH1A1KMT2AMEN1HTT | |
| SCHEMBL6588788 | 0.94 | PDK2 (0.35) | PDK2ALDH1A1KMT2AMEN1HTT | |
| SCHEMBL8557765 | 0.81 | PDK2 (0.32) | PDK2ALDH1A1KMT2AMEN1HTT | |
| SCHEMBL8557766 | 0.81 | PDK2 (0.32) | PDK2ALDH1A1KMT2AMEN1HTT | |
| SCHEMBL8555134 | 0.79 | ALDH1A1 (0.37) | PDK2ALDH1A1KMT2APDE4DTSHR | |
| SCHEMBL8559248 | 0.78 | ALDH1A1 (0.42) | PDK2ALDH1A1KMT2AMEN1HTT | |
| SCHEMBL8557018 | 0.78 | PDK2 (0.33) | PDK2ALDH1A1KMT2AMEN1HTT | |
| SCHEMBL8557014 | 0.78 | PDK2 (0.33) | PDK2ALDH1A1KMT2AMEN1HTT | |
| SCHEMBL8555928 | 0.77 | PDK2 (0.35) | PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957100-B1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | KOWA CO (JP) | 2004-10-27 | — | — | EP | disclosed |
| EP-0905134-B1 | Piperidine derivatives as LTD4 and H1 antagonists | KOWA CO (JP) | 2002-01-16 | — | — | EP | disclosed |
| US-6127360-A | ANTIHISTAMINES, ANTILEUKOTRIENES, ANTIINFLAMMATORY AGENTS, ANTIASTHMATIC AGENTS | KOWA CO., LTD. (JP) | 2000-10-03 | — | — | US | disclosed |
| US-6107308-A | ANTIHISTAMINE; LEUTRIENE ANTAGONIST | KOWA CO., LTD. (JP) | 2000-08-22 | — | — | US | disclosed |
| EP-0957100-A1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 1999-11-17 | — | — | EP | disclosed |
| EP-0905134-A1 | Piperidine derivatives as LTD4 and H1 antagonists | KOWA COMPANY, LTD. (JP) | 1999-03-31 | — | — | EP | disclosed |