Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 4/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.45 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6578697 | 0.86 | HPSE (0.47) | HPSEPARP1AURKBPRKD3MAP4K4 | |
| SCHEMBL3577852 | 0.85 | AURKB (0.61) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6591471 | 0.85 | PKN1 (0.56) | KDM4EALDH1A1SMN1; SMN2HPSEPARP1 | |
| SCHEMBL6582804 | 0.83 | HPSE (0.47) | KDM4EALDH1A1SMN1; SMN2HPSEPARP1 | |
| SCHEMBL7815539 | 0.78 | PARP1 (0.57) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3575386 | 0.77 | PARP1 (0.67) | PARP1AURKBPRKD3MAP4K4PIM1 | |
| SCHEMBL6584537 | 0.76 | MAP4K4 (0.67) | HPSEPARP1AURKBMAP4K4PIM1 | |
| SCHEMBL3585590 | 0.76 | PKN1 (0.54) | PARP1AURKBPRKD3MAP4K4PIM1 | |
| SCHEMBL3577856 | 0.74 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7474098 | 0.74 | PARP1 (0.44) | KDM4EALDH1A1SMN1; SMN2MAPTHPSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391457-B1 | Substituted 2-Phenylbenzimidazoles and their use as PARP inhibitors | ABBVIE DEUTSCHLAND (DE) | 2013-12-25 | — | — | EP | disclosed |
| EP-1127052-B1 | SUBSTITUTED 2-PHENYLBENZIMIDAZOLES, THE PRODUCTION THEREOF AND THEIR USE | ABBOTT GMBH & CO KG (DE) | 2004-12-08 | — | — | EP | disclosed |
| EP-1391457-A1 | Substituted 2-Phenylbenzimidazoles and their use as PARP inhibitors | Abbott GmbH & Co. KG (DE) | 2004-02-25 | — | — | EP | disclosed |