Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 17/20 | 0.39 |
| ▸ | VSIR | Q9H7M9 | 1/20 | 0.36 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6580677 | 0.92 | KDR (0.49) | KDRAURKBPARP1HPSE | |
| SCHEMBL3586249 | 0.88 | KDR (0.54) | KDRAURKBPARP1 | |
| SCHEMBL6581641 | 0.85 | AURKB (0.46) | KDRAURKBPARP1 | |
| SCHEMBL6580887 | 0.85 | PARP1 (0.40) | AURKBPARP1VSIRHPSE | |
| SCHEMBL3577370 | 0.79 | KDR (0.65) | KDRAURKBPARP1 | |
| SCHEMBL6581306 | 0.79 | PARP1 (0.41) | KDRAURKBPARP1HPSE | |
| SCHEMBL3586255 | 0.78 | KDR (0.41) | KDRAURKBPARP1 | |
| SCHEMBL6580981 | 0.77 | KDR (0.56) | KDRAURKBPARP1HPSE | |
| SCHEMBL6582934 | 0.72 | AURKB (0.51) | KDRAURKBPARP1HPSE | |
| SCHEMBL6385598 | 0.72 | PARP1 (0.56) | PARP1VSIRHPSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391457-B1 | Substituted 2-Phenylbenzimidazoles and their use as PARP inhibitors | ABBVIE DEUTSCHLAND (DE) | 2013-12-25 | — | — | EP | disclosed |
| EP-1127052-B1 | SUBSTITUTED 2-PHENYLBENZIMIDAZOLES, THE PRODUCTION THEREOF AND THEIR USE | ABBOTT GMBH & CO KG (DE) | 2004-12-08 | — | — | EP | disclosed |
| EP-1391457-A1 | Substituted 2-Phenylbenzimidazoles and their use as PARP inhibitors | Abbott GmbH & Co. KG (DE) | 2004-02-25 | — | — | EP | disclosed |