Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.65 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.65 |
| ▸ | PARP1 | P09874 | 19/20 | 0.55 |
| ▸ | DHODH | Q02127 | 1/20 | 0.51 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3586249 | 0.91 | KDR (0.54) | KDRAURKBPARP1DHODH | |
| SCHEMBL6580677 | 0.87 | KDR (0.49) | KDRAURKBPARP1DHODH | |
| SCHEMBL3582780 | 0.86 | AURKB (0.49) | KDRAURKBPARP1DHODH | |
| SCHEMBL3582141 | 0.84 | AURKB (0.75) | KDRAURKBPARP1DHODHPARP2 | |
| SCHEMBL6582952 | 0.79 | KDR (0.41) | KDRAURKBPARP1 | |
| SCHEMBL3577924 | 0.79 | AURKB (1.00) | KDRAURKBPARP1DHODHPARP2 | |
| SCHEMBL3578622 | 0.78 | AURKB (0.85) | KDRAURKBPARP1DHODH | |
| SCHEMBL3586255 | 0.78 | KDR (0.41) | KDRAURKBPARP1 | |
| SCHEMBL3582335 | 0.77 | AURKB (0.84) | KDRAURKBPARP1DHODHPARP2 | |
| SCHEMBL3577208 | 0.77 | PARP1 (0.55) | AURKBPARP1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |