Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.71 |
| ▸ | PDE4A | P27815 | 7/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8489189 | 0.89 | PDE4B (0.89) | PDE4BPDE4DPDE4APDE4CMAPK1 | |
| SCHEMBL6584071 | 0.87 | PDE4B (0.59) | PDE4BPDE4DPDE4APDE4CLMNA | |
| SCHEMBL6585357 | 0.85 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6585598 | 0.85 | PDE4B (0.57) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6584640 | 0.84 | PDE4B (0.61) | PDE4BPDE4DPDE4APDE4CMEN1 | |
| SCHEMBL6584651 | 0.83 | PDE4B (0.57) | PDE4BPDE4DPDE4APDE4C | |
| Daxalipram SCHEMBL7760245 | 0.83 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4CMAPK1 | |
| Daxalipram SCHEMBL450824 | 0.83 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4CMAPK1 | |
| Daxalipram SCHEMBL450823 | 0.83 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4CMAPK1 | |
| SCHEMBL6584797 | 0.79 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4CMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0928789-B1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2004-09-29 | — | — | EP | disclosed |
| US-6251897-B1 | TREATING DERMATITIS, ASTHMA | NIKKEN CHEMICALS CO., LTD (JP) | 2001-06-26 | — | — | US | disclosed |
| EP-0928789-A1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-07-14 | — | — | EP | disclosed |