Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.89 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.89 |
| ▸ | PDE4A | P27815 | 6/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Daxalipram SCHEMBL450824 | 0.94 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4CMAPK1 | |
| Daxalipram SCHEMBL450823 | 0.94 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4CMAPK1 | |
| Daxalipram SCHEMBL7760245 | 0.94 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4CMAPK1 | |
| SCHEMBL7760278 | 0.89 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4CMAPK1 | |
| SCHEMBL7763958 | 0.89 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4CMAPK1 | |
| SCHEMBL7764115 | 0.89 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4CMAPK1 | |
| SCHEMBL6582993 | 0.89 | PDE4B (0.71) | PDE4BPDE4DPDE4APDE4CMAPK1 | |
| SCHEMBL11435807 | 0.86 | PDE4B (0.77) | PDE4BPDE4DPDE4APDE4CLMNA | |
| SCHEMBL7763217 | 0.85 | PDE4B (0.75) | PDE4BPDE4DPDE4APDE4CMAPT | |
| SCHEMBL7764133 | 0.85 | PDE4B (0.75) | PDE4BPDE4DPDE4APDE4CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998453-A | ANTIINFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-12-07 | — | — | US | claimed |
| US-5783591-A | Administration of oxazolidinone and pyrolidinone compounds for the treatment of inflammation | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-07-21 | — | — | US | claimed |
| EP-0198919-B1 | PHARMACEUTICAL PREPARATIONS | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-02-28 | — | — | EP | claimed |
| EP-0198919-A1 | PHARMACEUTICAL PREPARATIONS. | SCHERING AG (DE) | 1986-10-29 | — | — | EP | claimed |
| WO-1986002268-A1 | PHARMACEUTICAL PREPARATIONS | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1986-04-24 | — | — | WO | claimed |
| US-5998453-A | ANTIINFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-12-07 | — | — | US | disclosed |
| US-5783591-A | Administration of oxazolidinone and pyrolidinone compounds for the treatment of inflammation | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-07-21 | — | — | US | disclosed |
| EP-0198919-B1 | PHARMACEUTICAL PREPARATIONS | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-02-28 | — | — | EP | disclosed |
| EP-0198919-A1 | PHARMACEUTICAL PREPARATIONS. | SCHERING AG (DE) | 1986-10-29 | — | — | EP | disclosed |
| WO-1986002268-A1 | PHARMACEUTICAL PREPARATIONS | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1986-04-24 | — | — | WO | disclosed |