Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586473 | 0.96 | HIF1A (0.49) | HIF1AMEN1KMT2AKDM4ETSHR | |
| SCHEMBL18306578 | 0.85 | POLB (0.51) | HIF1AMEN1KMT2AKDM4EGRM2 | |
| SCHEMBL8313269 | 0.81 | HTR3A (0.53) | — | |
| SCHEMBL6962681 | 0.77 | POLB (0.47) | MEN1KMT2AKDM4EL3MBTL1POLB | |
| SCHEMBL8315846 | 0.77 | HTR3A (0.49) | — | |
| SCHEMBL6585574 | 0.76 | GRM2 (0.67) | KDM4EGRM2POLBALDH1A1 | |
| SCHEMBL7481715 | 0.75 | GRM2 (0.65) | KDM4EGRM2POLBALDH1A1 | |
| SCHEMBL6151147 | 0.74 | MEN1 (0.58) | MEN1KMT2AKDM4EUSP2L3MBTL1 | |
| SCHEMBL9257050 | 0.73 | TSHR (0.50) | KMT2AKDM4EL3MBTL1POLBTSHR | |
| SCHEMBL6583086 | 0.72 | GRM2 (0.61) | KDM4EGRM2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957100-B1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | KOWA CO (JP) | 2004-10-27 | — | — | EP | disclosed |
| US-6127360-A | ANTIHISTAMINES, ANTILEUKOTRIENES, ANTIINFLAMMATORY AGENTS, ANTIASTHMATIC AGENTS | KOWA CO., LTD. (JP) | 2000-10-03 | — | — | US | disclosed |
| EP-0957100-A1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 1999-11-17 | — | — | EP | disclosed |