Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.49 |
| ▸ | WNT3A | P56704 | 1/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19462421 | 0.88 | KDM4E (0.52) | KDM4EPKMGPR119TGFBR1FAAH | |
| SCHEMBL6148442 | 0.85 | CYP2D6 (0.64) | KDM4EPKMGPR119TGFBR1CYP2D6 | |
| SCHEMBL1874817 | 0.83 | ALDH1A1 (0.61) | GPR119WNT3A | |
| SCHEMBL12696614 | 0.81 | FAAH (0.51) | KDM4EPKMGPR119WNT3AFAAH | |
| SCHEMBL12205335 | 0.81 | KDM4E (0.55) | KDM4EPKMGPR119TGFBR1CYP2D6 | |
| SCHEMBL3087666 | 0.80 | KDM4E (0.70) | KDM4EPKMGPR119TGFBR1CYP2D6 | |
| SCHEMBL19462008 | 0.80 | KDM4E (0.52) | KDM4EPKMGPR119TGFBR1FAAH | |
| SCHEMBL3032509 | 0.79 | TGFBR1 (0.56) | KDM4EPKMGPR119TGFBR1 | |
| SCHEMBL641072 | 0.79 | ALDH1A1 (0.53) | GPR119WNT3ABRD4 | |
| SCHEMBL18664141 | 0.79 | TGFBR1 (0.56) | KDM4EPKMGPR119TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1455788-A1 | 1-GLYCINYL-4-AMINOMETHYL-PIPERIDINE DERIVATIVES AS FACTOR XA INHIBITORS | ELI LILLY AND COMPANY (US) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003049737-A1 | CHEMICAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2003-06-19 | — | — | WO | disclosed |