Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583292 | 0.81 | KCNH2 (0.42) | KCNH2MAPTNR3C2 | |
| SCHEMBL6585164 | 0.77 | HSP90AA1 (0.36) | RAB9ASMN1; SMN2 | |
| SCHEMBL6583253 | 0.75 | GABRA1 (0.30) | — | |
| SCHEMBL7478263 | 0.73 | MEN1 (0.33) | MAPTNR3C2 | |
| SCHEMBL6581358 | 0.72 | LCK (0.45) | KCNH2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL27525212 | 0.70 | NR3C2 (0.42) | MAPTNR3C2SMN1; SMN2 | |
| SCHEMBL6142337 | 0.68 | RAB9A (0.35) | MAPTNR3C2RAB9ASMN1; SMN2MET | |
| SCHEMBL28745064 | 0.68 | MAPT (0.34) | KCNH2MAPTNR3C2 | |
| SCHEMBL2424903 | 0.66 | SMN1; SMN2 (0.42) | MAPTNR3C2RAB9ASMN1; SMN2 | |
| SCHEMBL4373422 | 0.65 | ALDH1A1 (0.53) | MAPTNR3C2RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037887-B1 | 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY | PROCTER & GAMBLE (US) | 2004-07-14 | — | — | EP | disclosed |