SCHEMBL6583320

SCHEMBL6583320

Cc1ccc(C2(OC=O)CC2)cc1[N+](=O)[O-]

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.49
TSHR P16473 3/20 0.49
CYP3A4 P08684 2/20 0.49
RECQL P46063 1/20 0.49
MCOLN3 Q8TDD5 2/20 0.39
CRHBP P24387 1/20 0.39
CRHR2 Q13324 1/20 0.39
MEN1 O00255 3/20 0.39
MAPT P10636 3/20 0.39
KMT2A Q03164 3/20 0.39
HSD17B10 Q99714 1/20 0.39
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38
GAA P10253 1/20 0.36
LMNA P02545 2/20 0.36
HPGD P15428 1/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6579375 0.75 TSHR (0.50) ALDH1A1TSHRCYP3A4RECQLMCOLN3
SCHEMBL24116620 0.72 TSHR (0.46) ALDH1A1TSHRCYP3A4RECQLMCOLN3
SCHEMBL6583318 0.72 TSHR (0.54) ALDH1A1TSHRCYP3A4RECQLMEN1
SCHEMBL17368518 0.70 ALDH1A1 (0.51) ALDH1A1TSHRCYP3A4RECQLMCOLN3
SCHEMBL22978368 0.69 ALDH1A1 (0.46) ALDH1A1TSHRCYP3A4RECQLMCOLN3
SCHEMBL335971 0.67 ALDH5A1 (0.62) ALDH1A1TSHRCYP3A4RECQLMEN1
SCHEMBL100616 0.67 TSHR (1.00) ALDH1A1TSHRCYP3A4RECQLMCOLN3
SCHEMBL29453602 0.67 TSHR (1.00) ALDH1A1TSHRCYP3A4RECQLMCOLN3
SCHEMBL12742441 0.66 POLB (0.41) ALDH1A1CYP3A4MEN1MAPTKMT2A
SCHEMBL29613904 0.66 TSHR (0.72) ALDH1A1TSHRCYP3A4RECQLMCOLN3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1037887-B1 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY PROCTER & GAMBLE (US) 2004-07-14 EP disclosed
US-6486190-B1 5-(2-imidazolinylamino)-benzimidazole derivatives, their preparation and their use as .alpha.-adrenoceptor agonists with improved metabolic stability THE PROCTER & GAMBLE COMPANY 2002-11-26 US disclosed
EP-1037887-A1 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY THE PROCTER & GAMBLE COMPANY (US) 2000-09-27 EP disclosed
WO-1999026942-A1 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY THE PROCTER & GAMBLE COMPANY (US) 1999-06-03 WO disclosed