Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | HPGD | P15428 | 3/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.74 |
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.74 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.74 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | PLAT | P00750 | 1/20 | 0.48 |
| ▸ | KLK1 | P06870 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL4292229 | 0.91 | ALDH1A1 (0.74) | ALDH1A1HPGDCYP3A4TSHRHSD17B10 | |
| Acetic Acid SCHEMBL27357071 | 0.89 | ALDH1A1 (0.71) | ALDH1A1HPGDCYP3A4TSHRHSD17B10 | |
| Acetic Acid SCHEMBL28299908 | 0.89 | ALDH1A1 (0.71) | ALDH1A1HPGDCYP3A4TSHRHSD17B10 | |
| Benzene SCHEMBL22289542 | 0.89 | ALDH1A1 (0.94) | ALDH1A1HPGDCYP3A4TSHRHSD17B10 | |
| Benzamide SCHEMBL28467901 | 0.87 | CYP3A4 (0.61) | ALDH1A1HPGDCYP3A4TSHRHSD17B10 | |
| SCHEMBL9029 | 0.86 | ALDH1A1 (1.00) | ALDH1A1HPGDCYP3A4TSHRHSD17B10 | |
| SCHEMBL29413841 | 0.86 | ALDH1A1 (1.00) | ALDH1A1HPGDCYP3A4TSHRHSD17B10 | |
| SCHEMBL4941999 | 0.86 | ALDH1A1 (1.00) | ALDH1A1HPGDCYP3A4TSHRHSD17B10 | |
| Benzoic Acid SCHEMBL27454196 | 0.86 | TSHR (0.65) | ALDH1A1HPGDCYP3A4TSHRHSD17B10 | |
| Propionic Acid SCHEMBL30668813 | 0.84 | ALDH1A1 (0.63) | ALDH1A1HPGDCYP3A4TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040259875-A1 | Amine derivatives | BAYER HEALTHCARE AG (DE) | 2004-12-23 | — | — | US | disclosed |
| EP-1414788-A1 | NAPHTHYLUREA AND NAPHTHYLACETAMIDE DERIVATIVES AS VANILLOID RECEPTOR 1 (VR1) ANTAGONISTS | Bayer HealthCare AG (DE) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003089404-A1 | NAPHTHALENE AMIDES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2003-10-30 | — | — | WO | disclosed |
| US-20030199578-A1 | Naphthalene amides as potassium channel openers | ABBOTT LABORATORIES | 2003-10-23 | — | — | US | disclosed |
| WO-2003014064-A1 | NAPHTHYLUREA AND NAPHTHYLACETAMIDE DERIVATIVES AS VANILLOID RECEPTOR 1 (VR1) ANTAGONISTS | BAYER HEALTHCARE AG (DE) | 2003-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199578-A1 | Naphthalene amides as potassium channel openers | KCNJ2, KCNN2, KCNJ1 | ALDH1A1 1856/4885HPGD 1386/4885CYP3A4 597/4885 |
| US-20040259875-A1 | Amine derivatives | AVPR1A, GRIN1, OPRL1 | ALDH1A1 714/4885HPGD 2073/4885CYP3A4 4160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.