Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | GLA | P06280 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8440119 | 1.00 | HTT (0.67) | HTTAKR1C3TP53ALDH1A1GLA | |
| SCHEMBL2710798 | 1.00 | HTT (0.67) | HTTAKR1C3TP53ALDH1A1GLA | |
| SCHEMBL28273258 | 0.91 | AKR1C3 (0.61) | HTTAKR1C3TP53ALDH1A1GLA | |
| SCHEMBL979463 | 0.91 | ALDH1A1 (0.67) | HTTAKR1C3TP53ALDH1A1GLA | |
| SCHEMBL39098 | 0.86 | TP53 (0.75) | HTTAKR1C3TP53ALDH1A1MAPT | |
| SCHEMBL4972255 | 0.86 | TP53 (0.68) | HTTAKR1C3TP53ALDH1A1MAPT | |
| SCHEMBL29898330 | 0.86 | TP53 (0.75) | HTTAKR1C3TP53ALDH1A1MAPT | |
| SCHEMBL4972259 | 0.86 | TP53 (0.68) | HTTAKR1C3TP53ALDH1A1MAPT | |
| SCHEMBL10824894 | 0.83 | AKR1C3 (0.53) | HTTAKR1C3TP53ALDH1A1GLA | |
| SCHEMBL10824896 | 0.83 | AKR1C3 (0.53) | HTTAKR1C3TP53ALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0240398-B1 | DISSYMMETRICAL 1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC-ACID DERIVATIVES, PREPARATION PROCESSES AND THERAPEUTICAL USE | FOURNIER INNOVATION ET SYNERGIE (FR) | 1991-05-15 | — | — | EP | claimed |
| EP-0371492-A2 | Process for the preparation of 1,4-dihydropyridine derivatives | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1990-06-06 | — | — | EP | claimed |
| EP-0197488-A2 | 1,4-Dihydropyiridine derivative, a process for preparing the same, a pharmaceutical composition as well as the use thereof | Eisai Co., Ltd. (JP) | 1986-10-15 | — | — | EP | claimed |
| EP-1443043-A2 | Highly selective process for the preparation of enantiomerically pure phenyl-substituted 1,4-dihydropyridine-3,5-dicarboxylic acid derivatives | Bayer HealthCare AG (DE) | 2004-08-04 | — | — | EP | disclosed |
| EP-1189958-B1 | TRIFUNCTIONAL OLEFINIC-CAPPED POLYMERS AND COMPOSITIONS THAT INCLUDE SUCH POLYMERS | LORD CORP (US) | 2003-08-27 | — | — | EP | disclosed |
| US-6562910-B2 | Polymer having end group or pendant functional group capped with a benzylidenecyanoacetate group; reacting hydroxy-terminated polybutadiene with methyl benzylidenecyanoacetate; curable mixtures; adhesives | LORD CORPORATION | 2003-05-13 | — | — | US | disclosed |
| US-6562181-B2 | Bonding together two substrates by applying to a first substrate formulation of mixture of trifunctional olefinic monomer, olefinic second monomer that is copolymerizable and free radical initiator; contacting second substrate | LORD CORPORATION | 2003-05-13 | — | — | US | disclosed |
| US-20030032732-A1 | Trifunctional olefinic-capped polymers and compositions that include such polymers | F RIGHETTINI ROBIN (US) | 2003-02-13 | — | — | US | disclosed |
| US-6515078-B1 | A polymer having at least one reactive terminal or pendant functional group that has been capped with a trifunctional olefinic compound. The polymer can be made by contacting a base polymer having at least one reactive terminal or pendant | LORD CORPORATION | 2003-02-04 | — | — | US | disclosed |
| US-6506844-B1 | Crosslinking toughening agents for adhesives, coatings, and composite matrices | LORD CORPORATION | 2003-01-14 | — | — | US | disclosed |
| US-20020129896-A1 | REACTIVE ADHESIVES AND COATINGS WITH TRIFUNCTIONAL OLEFINIC MONOMERS | LORD CORPORATION | 2002-09-19 | — | — | US | disclosed |
| EP-0197488-A2 | 1,4-Dihydropyiridine derivative, a process for preparing the same, a pharmaceutical composition as well as the use thereof | Eisai Co., Ltd. (JP) | 1986-10-15 | — | — | EP | disclosed |
| US-4446325-A | VASODILATION, HYPOTENSIVE AGENTS | MARUKO SEIYAKU CO., LTD. (JP) | 1984-05-01 | — | — | US | disclosed |
| US-4419518-A | VASODILATION, HYPOTENSIVE AGENTS | TOKYO TANABE CO. L.T.D. (JP) | 1983-12-06 | — | — | US | disclosed |
| US-4418197-A | VASODILATORS, HYPOTENSIVE AGENTS | TOKYO TANABE COMPANY, LIMITED (JP) | 1983-11-29 | — | — | US | disclosed |
| US-4261988-A | ANTICHOLESTEROL AGENTS USED IN ANIMAL HUSBANDRY | BAYER AKTIENGESELLSCHAFT (DE) | 1981-04-14 | — | — | US | disclosed |
| US-4038399-A | 1,4-DIHYDROPYRIDINE CARBOXYLIC ACID ESTERS USEFUL AS CORONARY VESSEL DILATORS AND ANTI-HYPERTENSIVES | BAYER AKTIENGESELLSCHAFT (DT) | 1977-07-26 | — | — | US | disclosed |
| US-4031104-A | ANTIHYPERTENSIVE AGENTS | BAYER AKTIENGESELLSCHAFT (DT) | 1977-06-21 | — | — | US | disclosed |
| US-3996234-A | CORONARY VESSEL DILATORS, HYPOTENSIVES | BAYER AKTIENGESELLSCHAFT (DT) | 1976-12-07 | — | — | US | disclosed |
| US-3974275-A | 1,4-Dihydropyridine carboxylic acid esters useful as coronary vessel dilators and anti-hypertensives | BAYER AKTIENGESELLSCHAFT (DT) | 1976-08-10 | — | — | US | disclosed |