Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | GABRP | O00591 | 2/20 | 0.45 |
| ▸ | GABRD | O14764 | 2/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.45 |
| ▸ | GABRE | P78334 | 2/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.45 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.45 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4027042 | 0.95 | ALDH1A1 (0.46) | ALDH1A1MAPTGABRA1GABRG2GABRB3 | |
| SCHEMBL15715983 | 0.82 | GABRA1 (0.49) | ALDH1A1MAPTGABRA1GABRG2GABRB3 | |
| SCHEMBL29840564 | 0.82 | LCK (0.56) | ALDH1A1MAPTGABRA1GABRG2GABRB3 | |
| SCHEMBL214090 | 0.82 | LCK (0.56) | ALDH1A1MAPTGABRA1GABRG2GABRB3 | |
| Hydrochloric Acid SCHEMBL27800514 | 0.80 | LCK (0.55) | ALDH1A1MAPTGABRA1GABRG2GABRB3 | |
| SCHEMBL8541158 | 0.79 | ALDH1A1 (0.47) | ALDH1A1MAPTGABRA1GABRG2GABRB3 | |
| SCHEMBL8544851 | 0.77 | CYP3A4 (0.39) | ALDH1A1MAPTGABRA1GABRG2GABRB3 | |
| SCHEMBL1202391 | 0.75 | LCK (0.50) | ALDH1A1MAPTKDM4ECYP1A2CYP2C19 | |
| SCHEMBL2444192 | 0.74 | GABRA1 (0.50) | ALDH1A1MAPTGABRA1GABRG2GABRB3 | |
| SCHEMBL1872723 | 0.74 | GABRA1 (0.50) | ALDH1A1MAPTGABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478363-A1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | Abbott Laboratories (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003070247-A1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2003-08-28 | — | — | WO | disclosed |