Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB1 | P11230 | 19/20 | 1.00 |
| ▸ | CHRNB2 | P17787 | 19/20 | 1.00 |
| ▸ | CHRNB4 | P30926 | 19/20 | 1.00 |
| ▸ | CHRNA3 | P32297 | 19/20 | 1.00 |
| ▸ | CHRNB3 | Q05901 | 19/20 | 1.00 |
| ▸ | JAK2 | O60674 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585020 | 1.00 | CHRNB1 (1.00) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL14311702 | 1.00 | CHRNB1 (1.00) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| Hydrochloric Acid SCHEMBL6589203 | 0.99 | CHRNB1 (0.98) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| Hydrochloric Acid SCHEMBL6583237 | 0.99 | CHRNB1 (0.98) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL6583152 | 0.93 | CHRNB2 (0.86) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| Hydrochloric Acid SCHEMBL6584062 | 0.91 | CHRNB2 (0.84) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL6582918 | 0.91 | CHRNB1 (1.00) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| Hydrochloric Acid SCHEMBL6583047 | 0.90 | CHRNB1 (0.98) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL6584016 | 0.89 | CHRNB2 (1.00) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL6583157 | 0.89 | CHRNB1 (1.00) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934308-B1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2004-08-11 | — | — | EP | claimed |
| US-6127386-A | STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS | ABBOTT LABORATORIES (US) | 2000-10-03 | — | — | US | claimed |
| US-20100129291-A1 | NICOTINIC DESENSITIZERS AND METHODS OF SELECTING, TESTING, AND USING THEM | BETHESDA PHARMACOLOGY ASSOCIATES (US) | 2010-05-27 | — | — | US | disclosed |
| EP-0934308-B1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2004-08-11 | — | — | EP | disclosed |
| US-20020151712-A1 | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission | LIN NAN-HORNG (US) | 2002-10-17 | — | — | US | disclosed |
| US-6437138-B1 | 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |
| US-6127386-A | STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS | ABBOTT LABORATORIES (US) | 2000-10-03 | — | — | US | disclosed |
| US-5629325-A | TREATMENT OF NERVOUS SYSTEM DISORDERS; NEURONAL NICOTINIC CHOLINERGIC COMPOUNDS | ABBOTT LABORATORIES (US) | 1997-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100129291-A1 | NICOTINIC DESENSITIZERS AND METHODS OF SELECTING, TESTING, AND USING THEM | CHRNA5, CHRNA2, CHRNA10 | CHRNB1 12/4885CHRNB2 7/4885CHRNB4 11/4885 |
| US-20020151712-A1 | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission | GAP43, SLC18A2, GABRE | CHRNB1 97/4885CHRNB2 16/4885CHRNB4 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.