Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.66 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.66 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.66 |
| ▸ | CHRNB1 | P11230 | 3/20 | 0.66 |
| ▸ | CHRNB3 | Q05901 | 3/20 | 0.66 |
| ▸ | AKT1 | P31749 | 6/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | PRKX | P51817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583881 | 1.00 | CHRNB2 (0.66) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL6583755 | 1.00 | CHRNB2 (0.66) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL6585964 | 0.94 | CHRNB2 (0.60) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL6581899 | 0.87 | CHRNB1 (0.49) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL6586070 | 0.87 | CHRNB1 (0.49) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL6581902 | 0.87 | CHRNB1 (0.49) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL6586068 | 0.87 | CHRNB1 (0.49) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL6584401 | 0.87 | CHRNB2 (0.47) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL6583081 | 0.86 | CHRNB2 (0.48) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL6585637 | 0.86 | CHRNB2 (0.48) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934308-B1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2004-08-11 | — | — | EP | disclosed |
| US-6437138-B1 | 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |
| US-6127386-A | STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS | ABBOTT LABORATORIES (US) | 2000-10-03 | — | — | US | disclosed |
| US-5629325-A | TREATMENT OF NERVOUS SYSTEM DISORDERS; NEURONAL NICOTINIC CHOLINERGIC COMPOUNDS | ABBOTT LABORATORIES (US) | 1997-05-13 | — | — | US | disclosed |