SCHEMBL6585964

SCHEMBL6585964

CC(C)(C)OC(=O)N1CC[C@H]1COc1cncc(C=Cc2ccncc2)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 4/20 0.60
CHRNB4 P30926 4/20 0.60
CHRNA3 P32297 4/20 0.60
CHRNB1 P11230 3/20 0.60
CHRNB3 Q05901 3/20 0.60
AKT1 P31749 9/20 0.52
ROCK2 O75116 5/20 0.44
ROCK1 Q13464 5/20 0.44
DYRK1A Q13627 5/20 0.44
PIM1 P11309 4/20 0.44
MAP4K4 O95819 4/20 0.44
PRKACA P17612 4/20 0.44
PKN2 Q16513 4/20 0.44
CLK4 Q9HAZ1 4/20 0.44
MKNK2 Q9HBH9 3/20 0.44
STK17A Q9UEE5 3/20 0.44
DYRK3 O43781 3/20 0.44
CLK2 P49760 3/20 0.44
PRKX P51817 3/20 0.44
PRKG1 Q13976 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6583758 0.94 CHRNB2 (0.66) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3
SCHEMBL6583755 0.94 CHRNB2 (0.66) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3
SCHEMBL6583881 0.94 CHRNB2 (0.66) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3
SCHEMBL7927287 0.87 CHRNB2 (0.44) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3
SCHEMBL6587463 0.86 AKT1 (0.48) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3
SCHEMBL7478448 0.86 CHRNB2 (0.42) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3
SCHEMBL6586940 0.83 DAPK3 (0.64) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3
SCHEMBL7465912 0.82 CHRNB2 (0.57) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3
SCHEMBL7475109 0.81 CHRNB2 (0.54) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3
SCHEMBL7475438 0.81 CHRNB2 (0.45) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934308-B1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LAB (US) 2004-08-11 EP disclosed
US-6437138-B1 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS ABBOTT LABORATORIES 2002-08-20 US disclosed
US-6127386-A STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS ABBOTT LABORATORIES (US) 2000-10-03 US disclosed
US-5629325-A TREATMENT OF NERVOUS SYSTEM DISORDERS; NEURONAL NICOTINIC CHOLINERGIC COMPOUNDS ABBOTT LABORATORIES (US) 1997-05-13 US disclosed