Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30800373 | 0.85 | MTNR1A (0.60) | MTNR1AMTNR1BTAAR1CASP3CASP7 | |
| SCHEMBL7331644 | 0.85 | MTNR1A (0.60) | MTNR1AMTNR1BTAAR1CASP3CASP7 | |
| SCHEMBL4684922 | 0.85 | CA12 (0.51) | KMT2AMEN1 | |
| SCHEMBL266525 | 0.84 | MTNR1A (0.63) | MTNR1AMTNR1BTAAR1CASP3CASP7 | |
| SCHEMBL30365164 | 0.84 | MTNR1A (0.63) | MTNR1AMTNR1BTAAR1CASP3CASP7 | |
| SCHEMBL29590071 | 0.84 | LMNA (0.59) | MTNR1AMTNR1BTAAR1 | |
| SCHEMBL362209 | 0.84 | LMNA (0.59) | MTNR1AMTNR1BTAAR1 | |
| SCHEMBL4685283 | 0.83 | L3MBTL1 (0.53) | KMT2AMEN1 | |
| SCHEMBL4743195 | 0.82 | MTNR1A (0.57) | MTNR1AMTNR1BTAAR1CASP3CASP7 | |
| SCHEMBL2437293 | 0.82 | TAAR1 (0.59) | MTNR1AMTNR1BTAAR1CASP3CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865430-B1 | 3-(4-SUBST.-PIPERIDINYL-1)-1-(3,4-DICHLOROPHENYL)PROPYL CARBAMATES AND UREAS AND DERIVATIVES AS NOVEL NEUROKININ ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-03-03 | — | — | EP | claimed |
| EP-0865430-A1 | 3-(4-SUBST.-PIPERIDINYL-1)-1-(3,4-DICHLOROPHENYL)PROPYL CARBAMATES AND UREAS AND DERIVATIVES AS NOVEL NEUROKININ ANTAGONISTS | AstraZeneca AB (SE) | 1998-09-23 | — | — | EP | claimed |
| WO-1997019060-A1 | 3-(4-SUBST.-PIPERIDINYL-1)-1-(3,4-DICHLOROPHENYL)PROPYL CARBAMATES AND UREAS AND DERIVATIVES AS NOVEL NEUROKININ ANTAGONISTS | ZENECA LIMITED (GB) | 1997-05-29 | — | — | WO | claimed |
| EP-0865430-B1 | 3-(4-SUBST.-PIPERIDINYL-1)-1-(3,4-DICHLOROPHENYL)PROPYL CARBAMATES AND UREAS AND DERIVATIVES AS NOVEL NEUROKININ ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-03-03 | — | — | EP | disclosed |
| WO-2001007409-A1 | CARBAZOLE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | ASTRAZENECA UK LIMITED (GB) | 2001-02-01 | — | — | WO | disclosed |
| US-6090824-A | Therapeutic neurokinin receptor antagonist compounds | ZENECA LIMITED (GB) | 2000-07-18 | — | — | US | disclosed |
| EP-0865430-A1 | 3-(4-SUBST.-PIPERIDINYL-1)-1-(3,4-DICHLOROPHENYL)PROPYL CARBAMATES AND UREAS AND DERIVATIVES AS NOVEL NEUROKININ ANTAGONISTS | AstraZeneca AB (SE) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997019060-A1 | 3-(4-SUBST.-PIPERIDINYL-1)-1-(3,4-DICHLOROPHENYL)PROPYL CARBAMATES AND UREAS AND DERIVATIVES AS NOVEL NEUROKININ ANTAGONISTS | ZENECA LIMITED (GB) | 1997-05-29 | — | — | WO | disclosed |