Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.50 |
| ▸ | DHFR | P00374 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566496 | 0.91 | RAB9A (0.61) | HRH4RAB9AADORA2AADORA1ADORA2B | |
| SCHEMBL25203716 | 0.87 | IDO1 (0.52) | HRH4RAB9ADHFRNPC1DPP4 | |
| SCHEMBL30476538 | 0.87 | IDO1 (0.52) | HRH4RAB9ADHFRNPC1DPP4 | |
| SCHEMBL17416252 | 0.87 | IDO1 (0.52) | HRH4RAB9ADHFRNPC1DPP4 | |
| SCHEMBL27795616 | 0.83 | RAB9A (0.49) | HRH4RAB9AADORA2AADORA1ADORA2B | |
| SCHEMBL20565978 | 0.81 | NR1I3 (0.53) | HRH4RAB9AADORA2AADORA1NPC1 | |
| SCHEMBL29664448 | 0.81 | NR1I3 (0.53) | HRH4RAB9AADORA2AADORA1NPC1 | |
| SCHEMBL30205277 | 0.81 | ADORA2A (0.72) | HRH4RAB9AADORA2AADORA1ADORA2B | |
| SCHEMBL2250601 | 0.81 | ADORA2A (0.72) | HRH4RAB9AADORA2AADORA1ADORA2B | |
| SCHEMBL10589866 | 0.80 | IDO1 (0.57) | HRH4RAB9ADHFRNPC1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390354-A1 | TRIAZINYL ACRYLAMIDE DERIVATIVES AS KINASE INHIBITORS | Amgen Inc. (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1385833-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | Amgen Inc. (US) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002083654-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |
| WO-2002083653-A1 | TRIAZINYL ACRYLAMIDE DERIVATIVES AS KINASE INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |
| US-4333933-A | ANTIINFLAMMATORY, REACTING HALO BENZOGUANAMINE WITH NICOTINE ACID DERIVAGIVE | NIPPON SHINYAKU CO., LTD. (JP) | 1982-06-08 | — | — | US | disclosed |