Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 15/20 | 0.55 |
| ▸ | EDNRA | P25101 | 6/20 | 0.48 |
| ▸ | EDNRB | P24530 | 4/20 | 0.48 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032703 | 0.93 | MYC (0.46) | DHPSEDNRAEDNRB | |
| SCHEMBL6584039 | 0.90 | DHPS (0.69) | DHPSEDNRAEDNRB | |
| SCHEMBL5036558 | 0.86 | DHPS (0.48) | DHPS | |
| SCHEMBL7997029 | 0.85 | EDNRA (0.49) | DHPSEDNRAEDNRB | |
| SCHEMBL4066782 | 0.85 | DHPS (0.66) | DHPSEDNRAEDNRB | |
| SCHEMBL5035324 | 0.83 | DHPS (0.53) | DHPSEDNRAEDNRB | |
| SCHEMBL4061140 | 0.82 | EDNRA (0.67) | DHPSEDNRAEDNRBABCC3ABCC4 | |
| SCHEMBL6966755 | 0.82 | EDNRA (0.74) | DHPSEDNRAEDNRBABCC3ABCC4 | |
| SCHEMBL30466195 | 0.82 | DHPS (0.47) | DHPSEDNRAEDNRBABCC3ABCC4 | |
| SCHEMBL6961606 | 0.81 | EDNRA (0.66) | DHPSEDNRAEDNRBABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0897914-B1 | Process for the preparation of 2,5-disubstitued pyridines | HOFFMANN LA ROCHE (CH) | 2004-05-26 | — | — | EP | claimed |
| EP-0799209-A1 | NOVEL SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-08 | — | — | EP | claimed |
| WO-1996019459-A1 | NOVEL SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-27 | — | — | WO | claimed |