Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.49 |
| ▸ | EDNRB | P24530 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.44 |
| ▸ | DHPS | P49366 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7997033 | 0.91 | EDNRB (0.49) | EDNRAEDNRBDHPSALDH1A1KDM4E | |
| SCHEMBL7993551 | 0.88 | EDNRA (0.49) | EDNRAEDNRBIRAK4DHPSPOLB | |
| SCHEMBL7996803 | 0.88 | EDNRA (0.48) | EDNRAEDNRBIRAK4DHPSPOLB | |
| SCHEMBL6584032 | 0.85 | DHPS (0.55) | EDNRAEDNRBDHPS | |
| SCHEMBL7997001 | 0.85 | EDNRA (0.51) | EDNRAEDNRBIRAK4 | |
| SCHEMBL5032703 | 0.85 | MYC (0.46) | EDNRAEDNRBDHPS | |
| SCHEMBL7993866 | 0.83 | EDNRB (0.55) | EDNRAEDNRBIRAK4DHPSPOLB | |
| SCHEMBL7997031 | 0.83 | EDNRB (0.59) | EDNRAEDNRBIRAK4DHPSPOLB | |
| SCHEMBL7993553 | 0.79 | DHPS (0.50) | EDNRAEDNRBIRAK4DHPSPOLB | |
| SCHEMBL5036558 | 0.79 | DHPS (0.48) | DHPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001081338-A1 | SUBSTITUTED SULFONYLAMINOPYRIMIDINES | ACTELION PHARMACEUTICALS LTD (CH) | 2001-11-01 | — | — | WO | disclosed |