Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.53 |
| ▸ | GHSR | Q92847 | 1/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.49 |
| ▸ | FAAH | O00519 | 2/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | ANPEP | P15144 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584070 | 1.00 | P2RX7 (0.53) | P2RX7GHSRMTNR1AMTNR1BFAAH | |
| SCHEMBL2548043 | 0.87 | P2RX7 (0.47) | P2RX7GHSRMTNR1AMTNR1BFAAH | |
| SCHEMBL30430294 | 0.87 | P2RX7 (0.47) | P2RX7GHSRMTNR1AMTNR1BFAAH | |
| SCHEMBL366547 | 0.84 | P2RX7 (0.55) | P2RX7GHSRMTNR1AMTNR1BFAAH | |
| SCHEMBL8569917 | 0.83 | GHSR (0.57) | P2RX7GHSRMTNR1AMTNR1BFAAH | |
| SCHEMBL7072069 | 0.81 | P2RX7 (0.52) | P2RX7GHSRMTNR1AMTNR1BFAAH | |
| SCHEMBL6941196 | 0.81 | P2RX7 (0.49) | P2RX7GHSRMTNR1AMTNR1BFAAH | |
| SCHEMBL346421 | 0.80 | PLAU (0.52) | P2RX7GHSRMTNR1AMTNR1BFAAH | |
| SCHEMBL30711622 | 0.80 | PLAU (0.52) | P2RX7GHSRMTNR1AMTNR1BFAAH | |
| SCHEMBL6642213 | 0.80 | GHSR (0.69) | P2RX7GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204352-B1 | INHIBITORS OF LYSINE GINGIPAIN | CORTEXYME INC (US) | 2020-07-01 | — | — | EP | disclosed |
| EP-1070708-B1 | Triazole derivatives | HOFFMANN LA ROCHE (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002024192-A1 | DIPEPTIDE LIGANDS OF THE NPFF RECEPTOR FOR TREATING PAIN AND HYPERALGESIA | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2002-03-28 | — | — | WO | disclosed |
| US-6265426-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | disclosed |
| EP-1070708-A1 | Triazole and imidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-01-24 | — | — | EP | disclosed |